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溶原性猪链球菌 SS2-4 分离株含有 SMP 噬菌体，与野生型分离株相比，斑马鱼的死亡率增加。

Lysogenic Streptococcus suis isolate SS2-4 containing prophage SMP showed increased mortality in zebra fish compared to the wild-type isolate.

机构信息

Key Lab Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

出版信息

PLoS One. 2013;8(1):e54227. doi: 10.1371/journal.pone.0054227. Epub 2013 Jan 10.

DOI:10.1371/journal.pone.0054227
PMID:23326601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3542266/
Abstract

Streptococcus suis (S. suis) infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2) being the most frequently isolated from diseased piglets. Little is known, however, about the pathogenesis and virulence factors of S. suis. Research on bacteriophages highlights a new area in S. suis research. A S. suis serotype 2 bacteriophage, designated SMP, has been previously isolated in our laboratory. Here, we selected a lysogenic isolate in which the SMP phage was integrated into the chromosome of strain SS2-4. Compared to the wild-type isolate, the lysogenic strain showed increased mortality in zebra fish. Moreover the sensitivity of the lysogenic strain to lysozyme was seven times higher than that of the wild-type.

摘要

猪链球菌（S. suis）感染被认为是全球养猪业的一个主要问题。根据荚膜类型，已经描述了 33 种 S. suis 血清型，其中血清型 2（SS2）是从患病仔猪中分离出来的最常见的血清型。然而，对于 S. suis 的发病机制和毒力因子知之甚少。噬菌体的研究突出了 S. suis 研究的一个新领域。我们实验室之前分离到一株猪链球菌 2 型噬菌体，命名为 SMP。在这里，我们选择了一个溶原性分离株，其中 SMP 噬菌体整合到 SS2-4 菌株的染色体中。与野生型分离株相比，溶原性分离株在斑马鱼中的死亡率更高。此外，溶原性分离株对溶菌酶的敏感性比野生型高 7 倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/de866b01cc5d/pone.0054227.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/e147be4bfc45/pone.0054227.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/f06ce5477d30/pone.0054227.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/de866b01cc5d/pone.0054227.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/e147be4bfc45/pone.0054227.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/330de199153b/pone.0054227.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/47b80bf8e3c0/pone.0054227.g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/f06ce5477d30/pone.0054227.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c9d/3542266/de866b01cc5d/pone.0054227.g007.jpg

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