Lee Sangmi, Lee Kyung A, Choi Gyu Yeon, Desai Mina, Lee Sun Hwa, Pang Myung-Geol, Jo Inho, Kim Young Ju
Department of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.
J Matern Fetal Neonatal Med. 2013 Jun;26(9):908-14. doi: 10.3109/14767058.2013.766686. Epub 2013 Feb 11.
We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females.
From 10 d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring.
The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p < 0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p < 0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin.
Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.
我们研究了孕期/哺乳期胎儿营养不足对内脏脂肪、血脂谱、瘦素和脂联素的影响，并考察了雄性和雌性之间的性别差异。
从妊娠第10天到足月妊娠并持续至哺乳期，对照孕鼠自由采食（AdLib）食物，而研究组孕鼠食物限制50%（FR）。采用交叉寄养技术来研究孕期和哺乳期FR的影响。在子代3周龄和6月龄时测定血脂谱、瘦素和脂联素水平。我们还测量了子代的内脏脂肪量。
6月龄FR/AdLib子代的内脏脂肪量高于对照组（p<0.05）。在6月龄子代中，FR/AdLib子代的甘油三酯和瘦素水平高于对照组（p<0.05）。雌性子代的甘油三酯、高密度脂蛋白胆固醇和脂联素水平较高，而雄性子代的低密度脂蛋白胆固醇和瘦素水平较高。
仅孕期胎儿营养不足会导致子代肥胖、血浆甘油三酯和瘦素水平升高，并存在性别差异。
