Okunieff P, Greenberg M D, Zietman A, Kahn J, Westgate S, Neuringer L J
Department of Radiation Medicine, Massachusetts General Hospital, Boston 02114.
J Clin Oncol. 1990 May;8(5):906-10. doi: 10.1200/JCO.1990.8.5.906.
Water-suppressed proton nuclear magnetic resonance (NMR) of plasma was proposed as a technique for detecting malignant tumors. In that analysis, bloods drawn from cancer patients at the Beth Israel Hospital (BIH; Boston, MA), were easily distinguished from normal subjects by measuring and averaging the proton NMR methyl and methylene line widths of plasma lipoproteins. We collected blood at the Massachusetts General Hospital (MGH), including from normal controls, patients with untreated and treated malignant tumors, and patients with nontumor diseases. The plasma NMR analyses were carried out blind. The code was not broken until all patient charts and pathology records were reviewed, plasma analyses were completed, and patients had been divided into appropriate clinical groups. Analysis of these data showed no differences between the means of the study groups (false-positive and false-negative frequencies 46% and 57%, respectively). An inverse correlation of methyl/methylene line widths with age (P less than .01), and a correlation with nitrate-requiring cardiovascular disease (P less than .05) was, however, evident. This test cannot be validly used to detect malignancy.
血浆的水抑制质子核磁共振（NMR）被提议作为一种检测恶性肿瘤的技术。在该分析中，通过测量并平均血浆脂蛋白的质子NMR甲基和亚甲基线宽，从贝斯以色列医院（BIH；马萨诸塞州波士顿）的癌症患者采集的血液很容易与正常受试者区分开来。我们在马萨诸塞州总医院（MGH）采集血液，包括正常对照、未治疗和已治疗的恶性肿瘤患者以及非肿瘤疾病患者。血浆NMR分析是在不知情的情况下进行的。直到所有患者病历和病理记录被查阅、血浆分析完成且患者被分为适当的临床组后，编码才被破解。对这些数据的分析表明研究组均值之间无差异（假阳性和假阴性频率分别为46%和57%）。然而，甲基/亚甲基线宽与年龄呈负相关（P小于0.01），且与需要硝酸盐治疗的心血管疾病呈正相关（P小于0.05）。该检测不能有效地用于检测恶性肿瘤。
