Nabholtz J M, Rossignol A, Farnier M, Gambert P, Tremeaux J C, Friedman S, Guerrin J
Centre Georges-François Leclerc, UA33 CNRS, Faculte des Sciences, Hospital du Bocage, Villejuif, France.
Acta Oncol. 1988;27(5):479-82. doi: 10.3109/02841868809093574.
A recent study (N. Eng. J. Med. 315 (1986), 1369), described a method of detecting malignant tumors by water-suppressed proton nuclear magnetic resonance (1 H NMR) study of plasma. We performed a similar study of the W 1/2, a mean of the full width at half height of the resonances of the methyl and methylene groups of the lipids of plasma lipoproteins which is inversely related to the spin-spin apparent relaxation time (T 2*). W 1/2 values were measured at a fixed baseline width of 310 Hz. The study was prospective and blinded and comprised 182 subjects consisting of 40 controls, 68 patients with untreated malignancies, 45 with malignant tumors undergoing therapy and 29 benign tumor patients. No differences were seen between any groups that could serve as a basis for a useful clinical test. The major difficulty in the determination of W 1/2 was due to interference of metabolite protons (particularly lactate) within the lipoprotein resonance signal. Triglyceride level was seen to correlate inversely with W 1/2 within malignant patient groups. These discrepant results may be related to differing triglyceride-rich very low density lipoprotein (VLDL) levels in the patient populations of each study. We conclude that the water-suppressed 1H NMR of plasma lipoproteins is not a valid measurement for assessing malignancy.
最近一项研究（《新英格兰医学杂志》315卷（1986年），第1369页）描述了一种通过对血浆进行水抑制质子核磁共振（1H NMR）研究来检测恶性肿瘤的方法。我们对W1/2进行了类似的研究，W1/2是血浆脂蛋白脂质中甲基和亚甲基共振峰半高全宽的平均值，它与自旋-自旋表观弛豫时间（T2*）呈负相关。W1/2值在固定基线宽度310Hz下测量。该研究是前瞻性且盲法的，包括182名受试者，其中有40名对照者、68名未治疗的恶性肿瘤患者、45名正在接受治疗的恶性肿瘤患者和29名良性肿瘤患者。各组之间未发现可作为有效临床检测依据的差异。测定W1/2的主要困难在于脂蛋白共振信号内代谢物质子（特别是乳酸）的干扰。在恶性患者组中，甘油三酯水平与W1/2呈负相关。这些相互矛盾的结果可能与每项研究患者群体中富含甘油三酯的极低密度脂蛋白（VLDL）水平不同有关。我们得出结论，血浆脂蛋白的水抑制1H NMR并非评估恶性肿瘤的有效检测方法。
