Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Endocr J. 2013;60(2):237-43. doi: 10.1507/endocrj.ej12-0307. Epub 2013 Jan 18.
We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI ≥ 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non-DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI<25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required.
我们研究了 RETN（抵抗素）-420C>G 多态性（rs1862513）与日本人群糖尿病（DM）风险的关联，同时考虑了生活方式因素。研究对象为 J-MICC 研究的参与者，共有 2651 名年龄在 35-69 岁的参与者在知情同意后提供了血液用于基因分型和生活方式数据。采用非条件逻辑回归模型估计 RETN-420G/G 基因型发生 DM 的比值比（OR）。在 RETN-420G/G 基因型与 BMI<25 之间观察到 DM 风险的显著交互作用（交互作用的 OR = 0.12；P = 0.046），当将 RETN-420C/C+C/G 基因型且 BMI≥25（DM 患者 69 例，非 DM 患者 544 例）的受试者定义为参照时，RETN-420G/G 基因型且 BMI>25（DM 患者 10 例，非 DM 患者 111 例）、RETN-420C/C+C/G 且 BMI<25（DM 患者 81 例，非 DM 患者 1605 例）和 RETN-420G/G 且 BMI<25（DM 患者 1 例，非 DM 患者 230 例）的校正 OR 分别为 0.72（95%置信区间：0.36-1.46）、0.40（0.28-0.56）和 0.03（0.005-0.25）。本研究表明，RETN-420G/G 基因型与较低 BMI 之间存在显著的交互作用，降低了 DM 的风险，但方向与日本人群的报道结果相反。由于样本量有限，我们在解释本研究结果时应谨慎。需要进一步研究这种关联以及 RETN 在包括 DM 在内的人类代谢紊乱发生中的实际生物学作用。
