Gökdeniz Tayyar, Turan Turhan, Aykan Ahmet Çağrı, Gül Ilker, Boyacı Faruk, Hatem Engin, Bektaş Hüseyin, Celik Sükrü
Department of Cardiology, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey.
Cardiology. 2013;124(1):41-8. doi: 10.1159/000345298. Epub 2013 Jan 11.
Arterial stiffness and epicardial fat thickness (EFT) are associated with coronary artery disease (CAD). The cardio-ankle vascular index (CAVI) is a novel marker of arterial stiffness. The SYNTAX score (SS) reflects the complexity of CAD. We aimed to evaluate the relation of EFT and CAVI with CAD complexity in nondiabetic patients.
We enrolled 121 patients undergoing coronary angiography. In all patients, CAVI and EFT were determined. SS were calculated. The relationship between EFT, CAVI and SS was analyzed.
CAVI and EFT were significantly correlated with SS (r = 0.537, p < 0.001, and r = 0.629, p < 0.001, respectively) and found to be independent predictors of intermediate-high SS. For the prediction of intermediate-high SS, receiver-operating characteristic curve analysis revealed a cutoff value of 5 mm for EFT (area under the curve, AUC = 0.851, 95% confidence interval, CI, 0.775-0.910) with a specificity of 92.2% and a sensitivity of 77.4% and 8.6 for CAVI (AUC = 0.877, 95% CI 0.805-0.929) with a specificity of 68.9% and a sensitivity of 93.5%.
CAD complexity is associated with adverse cardiovascular events. It can be predicted noninvasively with EFT and CAVI in nondiabetic patients with suspected CAD. Thus, patients at high risk for cardiovascular events may be detected early and managed with appropriate treatment strategies.
动脉僵硬度和心外膜脂肪厚度（EFT）与冠状动脉疾病（CAD）相关。心踝血管指数（CAVI）是一种新的动脉僵硬度标志物。SYNTAX评分（SS）反映CAD的复杂性。我们旨在评估非糖尿病患者中EFT和CAVI与CAD复杂性的关系。
我们纳入了121例行冠状动脉造影的患者。测定所有患者的CAVI和EFT。计算SS。分析EFT、CAVI与SS之间的关系。
CAVI和EFT与SS显著相关（分别为r = 0.537，p < 0.001和r = 0.629，p < 0.001），并被发现是中高SS的独立预测因素。对于中高SS的预测，受试者工作特征曲线分析显示EFT的截断值为5 mm（曲线下面积，AUC = 0.851，95%置信区间，CI，0.775 - 0.910），特异性为92.2%，敏感性为77.4%；CAVI的截断值为8.6（AUC = 0.877，95% CI 0.805 - 0.929），特异性为68.9%，敏感性为93.5%。
CAD复杂性与不良心血管事件相关。在疑似CAD的非糖尿病患者中，可通过EFT和CAVI进行无创预测。因此，心血管事件高危患者可能被早期检测出来，并采用适当的治疗策略进行管理。
