Aykan A Ç, Gökdeniz T, Boyacı F, Gül I, Hatem E, Kalaycıoğlu E, Turan T, Bektaş H, Cilingir M B, Aykan D A, Ayyıldız F, Altun S
Department of Cardiology, Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Soğuksu Mahallesi, Çamlık Caddesi, 61040, Trabzon, Turkey,
Herz. 2014 Nov;39(7):822-7. doi: 10.1007/s00059-013-3902-3. Epub 2013 Aug 3.
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of cardiovascular morbidity and mortality. Increased arterial stiffness is associated with the presence and severity of cardiovascular disease. The cardio-ankle vascular index (CAVI) is a new method for assessment of arterial stiffness that is not influenced by blood pressure at the time of measurement and is significantly correlated with the presence and severity of cardiovascular disease. The aim of the present study was to evaluate whether there is an association between the spirometric severity of COPD, according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, with arterial stiffness as assessed by CAVI.
We enrolled 123 patients with COPD (102 men) followed up by the chest medicine outpatient clinics and 35 healthy subjects (26 men). All patients were assessed with spirometry, CAVI, and clinical history.
Patients with COPD had significantly increased CAVI values compared with control subjects (10.37 ± 2.26 vs. 6.74 ± 1.42, p < 0.001). CAVI was correlated with FEV1 % predicted, FEV1/FVC, and COPD stage (r: - 0.54, p < 0.001; r: - 0.58, p < 0.001 and r: 0.78, p < 0.001, respectively). Multivariate regression analysis showed that CAVI was independently associated with GOLD stages (p < 0.001).
In this study, we have shown that increased arterial stiffness assessed by CAVI is associated with the spirometric severity of COPD.
慢性阻塞性肺疾病（COPD）患者发生心血管疾病的发病率和死亡率增加。动脉僵硬度增加与心血管疾病的存在及严重程度相关。心踝血管指数（CAVI）是一种评估动脉僵硬度的新方法，不受测量时血压的影响，且与心血管疾病的存在及严重程度显著相关。本研究的目的是根据慢性阻塞性肺疾病全球倡议（GOLD）标准，评估COPD的肺量计严重程度与通过CAVI评估的动脉僵硬度之间是否存在关联。
我们纳入了123例由胸科门诊随访的COPD患者（102例男性）和35名健康受试者（26例男性）。所有患者均接受了肺量计检查、CAVI测量及临床病史评估。
与对照组相比，COPD患者的CAVI值显著升高（10.37±2.26 vs. 6.74±1.42，p<0.001）。CAVI与预测的FEV1%、FEV1/FVC及COPD分期相关（r分别为-0.54，p<0.001；r为-0.58，p<0.001；r为0.78，p<0.001）。多因素回归分析显示，CAVI与GOLD分期独立相关（p<0.001）。
在本研究中，我们表明通过CAVI评估的动脉僵硬度增加与COPD的肺量计严重程度相关。
