Gökdeniz Tayyar, Kalaycıoğlu Ezgi, Aykan Ahmet Çağrı, Boyacı Faruk, Turan Turhan, Gül İlker, Çavuşoğlu Gökhan, Dursun İhsan
Departamento de Cardiologia, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.
Departamento de Cardiologia, Akcabat State Hospital, Trabzon, Turquia.
Arq Bras Cardiol. 2014 Feb;102(2):120-7. doi: 10.5935/abc.20130241. Epub 2013 Dec 14.
Prediction of severity or complexity of coronary artery disease (CAD) is valuable owing to increased risk for cardiovascular events. Although the association between total coronary artery calcium (CAC) score and severity of CAD, Gensini score was not used, it has been previously demonstrated. There is no information about the association between total CAC score and complexity of CAD.
To investigate the association between severity or complexity of coronary artery disease (CAD) assessed by Gensini score and SYNTAX score (SS), respectively, and coronary artery calcium (CAC) score, which is a noninvasive method for CAD evaluation in symptomatic patients with accompanying significant CAD.
Two-hundred-fourteen patients were enrolled. Total CAC score was obtained before angiography. Severity and complexity of CAD was assessed by Gensini score and SS, respectively. Associations between clinical and angiographic parameters and total CAC score were analyzed.
Median total CAC score was 192 (23.0-729.8), and this was positively correlated with both Gensini score (r: 0.299, p<0.001) and SS (r: 0.577, p<0.001). At multivariate analysis, it was independently associated with age (ß: 0.154, p: 0.027), male gender (ß: 0.126, p: 0.035) and SS (ß: 0.481, p<0.001). Receiver-operating characteristic (ROC) curve analysis revealed a cut-off value>809 for SS>32 (high SS tertile).
In symptomatic patients with accompanying significant CAD, total CAC score was independently associated with SS and patients with SS>32 may be detected through high Agatston score.
由于心血管事件风险增加，预测冠状动脉疾病（CAD）的严重程度或复杂性具有重要价值。尽管总冠状动脉钙化（CAC）评分与CAD严重程度之间的关联（未使用Gensini评分）此前已有报道，但尚无关于总CAC评分与CAD复杂性之间关联的信息。
分别研究通过Gensini评分和SYNTAX评分（SS）评估的冠状动脉疾病（CAD）的严重程度或复杂性与冠状动脉钙化（CAC）评分之间的关联，CAC评分是一种用于有明显CAD症状患者的CAD无创评估方法。
纳入214例患者。在血管造影术前获取总CAC评分。分别通过Gensini评分和SS评估CAD的严重程度和复杂性。分析临床和血管造影参数与总CAC评分之间的关联。
总CAC评分中位数为192（23.0 - 729.8），与Gensini评分（r：0.299，p<0.001）和SS（r：0.577，p<0.001）均呈正相关。多因素分析显示，它与年龄（β：0.154，p：0.027）、男性（β：0.126，p：0.035）和SS（β：0.481，p<0.001）独立相关。受试者操作特征（ROC）曲线分析显示，对于SS>32（高SS三分位数），截断值>809。
在有明显CAD症状的患者中，总CAC评分与SS独立相关，且SS>32的患者可通过高阿加特斯顿评分检测出来。
