Weng Chuan-bo, Qian Ruo-bing, Fu Xian-ming, Lin Bin, Ji Xue-bing, Niu Chao-shi, Wang Ye-han
Department of Neurosurgery, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
Zhonghua Yi Xue Za Zhi. 2012 Dec 4;92(45):3221-3.
To explore the possible brain mechanism of online game addiction (OGA) in terms of brain morphology through voxel-based morphometric (VBM) analysis.
Seventeen subjects with OGA and 17 age- and gender-matched healthy controls (HC group) were recruited from Department of Psychology at our hospital during February-December 2011. The internet addiction scale (IAS) was used to measure the degree of OGA tendency. Magnetic resonance imaging (MRI) scans were performed to acquire 3-dimensional T1-weighted images. And FSL 4.1 software was employed to confirm regional gray matter volume changes. For the regions where OGA subjects showed significantly different gray matter volumes from the controls, the gray matter volumes of these areas were extracted, averaged and regressed against the scores of IAS.
The OGA group had lower gray matter volume in left orbitofrontal cortex (OFC), left medial prefrontal cortex (mPFC), bilateral insula (INS), left posterior cingulate cortex (PCC) and left supplementary motor area (SMA). Gray matter volumes of left OFC and bilateral INS showed a negative correlation with the scores of IAS (r = -0.65, r = -0.78, P < 0.05).
Gray matter volume changes are present in online game addicts and they may be correlated with the occurrence and maintenance of OGA.
通过基于体素的形态学测量（VBM）分析，从脑形态学角度探讨网络游戏成瘾（OGA）可能的脑机制。
2011年2月至12月期间，从我院心理科招募了17名患有OGA的受试者和17名年龄及性别匹配的健康对照者（HC组）。使用网络成瘾量表（IAS）来测量OGA倾向程度。进行磁共振成像（MRI）扫描以获取三维T1加权图像。并采用FSL 4.1软件来确认局部灰质体积变化。对于OGA受试者与对照组灰质体积存在显著差异的区域，提取这些区域的灰质体积，求平均值并与IAS得分进行回归分析。
OGA组在左侧眶额皮质（OFC）、左侧内侧前额叶皮质（mPFC）、双侧脑岛（INS）、左侧后扣带回皮质（PCC）和左侧辅助运动区（SMA）的灰质体积较低。左侧OFC和双侧INS的灰质体积与IAS得分呈负相关（r = -0.65，r = -0.78，P < 0.05）。
网络游戏成瘾者存在灰质体积变化，且这些变化可能与OGA的发生和维持有关。
