Dalian Medical University, Department of Psychiatry and Behavioural Sciences, Dalian, China.
Behav Brain Res. 2012 Aug 1;233(2):563-76. doi: 10.1016/j.bbr.2012.05.005. Epub 2012 Jun 6.
To study crave-related cerebral regions induced by game figure cues in online game addicts. fMRI brain imaging was done when the subjects were shown picture cues of the WoW (World of Warcraft, Version: 4.1.014250) game.
10 male addicts of WoW were selected as addicts' group, and 10 other healthy male non-addicts who were matched by age, were used as non-game addicts' group. All volunteers participated in fMRI paradigms. WoW associated cue pictures and neutral pictures were shown. We examined functional cerebral regions activated by the pictures with 3.0 T Philips MRI. The imaging signals' database was analyzed by SPM5. The correlation between game craving scores and different image results were assessed.
When the game addicts watch the pictures, some brain areas show increased signal activity namely: dorsolateral prefrontal cortex, bilateral temporal cortex, cerebellum, right inferior parietal lobule, right cuneus, right hippocampus, parahippocampal gyrus, left caudate nucleus. But in these same brain regions we did not observe remarkable activities in the control group. Differential image signal densities of the addict group were subtracted from the health control group, results of which were expressed in the bilateral dorsolateral prefrontal cortex, anterior cingulate cortex, inferior parietal lobe and inferior temporal gyrus, cerebellum, right insular and the right angular gyrus. The increased imaging signal densities were significant and positively correlated with the craving scale scores in the bilateral prefrontal cortex, anterior cingulate cortex and right inferior parietal lobe.
Craving of online game addicts was successfully induced by game cue pictures. Crave related brain areas are: dorsolateral prefrontal cortex, anterior cingulate cortex, and right inferior parietal lobe. The brain regions are overlapped with cognitive and emotion related processing brain areas.
研究网络游戏成瘾者观看游戏人物线索时与渴求相关的脑区。对受试者观看魔兽世界（WoW，版本：4.1.014250）游戏人物线索的图片时进行 fMRI 脑成像。
选择 10 名男性 WoW 成瘾者作为成瘾者组，选择 10 名年龄匹配的健康男性非成瘾者作为非游戏成瘾者组。所有志愿者均参加 fMRI 范式。呈现 WoW 相关线索图片和中性图片。我们使用 3.0T Philips MRI 检查图片激活的功能脑区。通过 SPM5 分析成像信号数据库。评估游戏渴求评分与不同图像结果之间的相关性。
当游戏成瘾者观看图片时，一些大脑区域的信号活动增加，包括背外侧前额叶皮层、双侧颞叶皮层、小脑、右侧顶下小叶、右侧楔前叶、右侧海马、海马旁回、左侧尾状核。但在对照组中，我们没有观察到这些大脑区域有显著的活动。将成瘾组与健康对照组的差分图像信号密度进行相减，结果以双侧背外侧前额叶皮层、前扣带皮层、顶下小叶和颞下回、小脑、右侧岛叶和右侧角回的形式表示。增加的成像信号密度与双侧前额叶皮层、前扣带皮层和右侧顶下小叶的渴求量表评分显著正相关。
网络游戏成瘾者的渴求可以通过游戏线索图片成功诱发。与渴求相关的脑区包括背外侧前额叶皮层、前扣带皮层和右侧顶下小叶。这些脑区与认知和情绪相关的处理脑区重叠。
