Fundación IVI-Instituto Universitario IVI-Universidad de Valencia, INCLIVA, Paterna, Valencia, Spain.
Semin Reprod Med. 2013 Jan;31(1):69-76. doi: 10.1055/s-0032-1331800. Epub 2013 Jan 17.
The existence of human endometrial somatic stem cells was proposed in the mid-20th century for the first time. This hypothesis became stronger and was revised by two authors between 1978 and 1989. Nevertheless, it was not until 2004 that scientific evidence was first published. As we describe here, the great regenerative capability of the human endometrium has been finally questioned in the last 8 years, and this period can be considered the most productive in endometrial stem cell biology given the new scientific information recapitulated to date. We provide a detailed summary based on the actual scientific knowledge obtained about (1) the existence of somatic stem cells in murine (detected with label-retaining cell methods) and human (cells isolated by different methods) endometria, (2) the involvement of bone marrow as a putative extrauterine source of endometrial somatic stem cells, (3) the implication and biological pathways of these cells in several pathologies like endometriosis and endometrial cancer, and (4) the future of endometrial somatic stem cells in regenerative medicine to provide new strategies in autologous transplant and bioengineering.
人类子宫内膜体干细胞的存在于 20 世纪中叶首次被提出。这一假说在 1978 年至 1989 年期间得到了两位作者的进一步支持和修正。然而，直到 2004 年才首次发表了科学证据。正如我们在这里所描述的，人类子宫内膜的巨大再生能力在过去的 8 年中受到了质疑，而考虑到迄今为止所概括的新科学信息，这一时期可以被认为是子宫内膜干细胞生物学最具创新性的时期。我们提供了一个详细的总结，基于关于（1）在鼠类（通过标记保留细胞方法检测到）和人类（通过不同方法分离的细胞）子宫内膜中存在体干细胞，（2）骨髓作为子宫内膜体干细胞的潜在的子宫外来源的参与，（3）这些细胞在子宫内膜异位症和子宫内膜癌等几种病理中的作用和生物学途径，以及（4）子宫内膜体干细胞在再生医学中的未来，为自体移植和生物工程提供新的策略。
