细菌蛋白 N-糖基化：新视角与新应用。
Bacterial protein N-glycosylation: new perspectives and applications.
机构信息
Alberta Glycomics Centre and Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
出版信息
J Biol Chem. 2013 Mar 8;288(10):6912-20. doi: 10.1074/jbc.R112.417857. Epub 2013 Jan 17.
Abstract
Protein glycosylation is widespread throughout all three domains of life. Bacterial protein N-glycosylation and its application to engineering recombinant glycoproteins continue to be actively studied. Here, we focus on advances made in the last 2 years, including the characterization of novel bacterial N-glycosylation pathways, examination of pathway enzymes and evolution, biological roles of protein modification in the native host, and exploitation of the N-glycosylation pathways to create novel vaccines and diagnostics.
摘要
蛋白质糖基化广泛存在于所有三个生命领域。细菌蛋白 N-糖基化及其在工程重组糖蛋白中的应用仍在积极研究中。在这里，我们重点介绍了过去 2 年取得的进展，包括新型细菌 N-糖基化途径的特征、途径酶和进化的研究、蛋白质修饰在天然宿主中的生物学作用以及利用 N-糖基化途径创造新型疫苗和诊断方法。
相似文献
1
Bacterial protein N-glycosylation: new perspectives and applications.细菌蛋白 N-糖基化：新视角与新应用。
J Biol Chem. 2013 Mar 8;288(10):6912-20. doi: 10.1074/jbc.R112.417857. Epub 2013 Jan 17.
2
Production of secretory and extracellular N-linked glycoproteins in Escherichia coli.大肠杆菌中分泌型和细胞外 N-连接糖蛋白的产生。
Appl Environ Microbiol. 2011 Feb;77(3):871-81. doi: 10.1128/AEM.01901-10. Epub 2010 Dec 3.
3
Sugar and Spice Make Bacteria Not Nice: Protein Glycosylation and Its Influence in Pathogenesis.甜蜜与刺激让细菌不再美好：蛋白质糖基化及其在发病机制中的影响
J Mol Biol. 2016 Aug 14;428(16):3206-3220. doi: 10.1016/j.jmb.2016.04.013. Epub 2016 Apr 20.
4
Expanding the glycoengineering toolbox: the rise of bacterial N-linked protein glycosylation.扩展糖基工程工具包：细菌 N 连接蛋白糖基化的兴起。
Trends Biotechnol. 2013 May;31(5):313-23. doi: 10.1016/j.tibtech.2013.03.003. Epub 2013 Apr 11.
5
Mycobacterial glycoproteins: a novel subset of vaccine candidates.分枝杆菌糖蛋白：一类新型候选疫苗
Front Cell Infect Microbiol. 2014 Sep 17;4:133. doi: 10.3389/fcimb.2014.00133. eCollection 2014.
6
Functional characterization of bacterial oligosaccharyltransferases involved in O-linked protein glycosylation.参与O-连接蛋白糖基化的细菌寡糖基转移酶的功能表征
J Bacteriol. 2007 Nov;189(22):8088-98. doi: 10.1128/JB.01318-07. Epub 2007 Sep 21.
7
Modification of the Campylobacter jejuni N-linked glycan by EptC protein-mediated addition of phosphoethanolamine.EptC 蛋白介导的磷酸乙醇胺添加修饰空肠弯曲菌 N-连接聚糖。
J Biol Chem. 2012 Aug 24;287(35):29384-96. doi: 10.1074/jbc.M112.380212. Epub 2012 Jul 2.
8
N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli.空肠弯曲菌中的N-连接糖基化及其向大肠杆菌的功能转移。
Science. 2002 Nov 29;298(5599):1790-3. doi: 10.1126/science.298.5599.1790.
9
Improving N-glycosylation efficiency in Escherichia coli using shotgun proteomics, metabolic network analysis, and selective reaction monitoring.利用鸟枪法蛋白质组学、代谢网络分析和选择反应监测提高大肠杆菌中的 N-糖基化效率。
Biotechnol Bioeng. 2011 Apr;108(4):902-12. doi: 10.1002/bit.23011. Epub 2010 Dec 22.
10
Remodeling of host glycoproteins during bacterial infection.宿主糖蛋白在细菌感染期间的重塑。
BMB Rep. 2021 Nov;54(11):541-544. doi: 10.5483/BMBRep.2021.54.11.129.
引用本文的文献
1
Sugar-coated bullets: Unveiling the enigmatic mystery 'sweet arsenal' in osteoarthritis.糖衣炮弹：揭开骨关节炎中神秘的“甜蜜武器库”之谜。
Heliyon. 2024 Mar 11;10(6):e27624. doi: 10.1016/j.heliyon.2024.e27624. eCollection 2024 Mar 30.
2
Considerations for Glycoprotein Production.糖蛋白生产的注意事项。
Methods Mol Biol. 2024;2762:329-351. doi: 10.1007/978-1-0716-3666-4_20.
3
Characterization of PglJ, a Glycosyltransferase in the N-Linked Protein Glycosylation Pathway that Expands Glycan Diversity.鉴定 PglJ，一种 N-连接蛋白糖基化途径中的糖基转移酶，可扩展聚糖多样性。
Biochemistry. 2024 Jan 2;63(1):141-151. doi: 10.1021/acs.biochem.3c00564. Epub 2023 Dec 18.
4
Post-translational modification by the Pgf glycosylation machinery modulates Streptococcus mutans OMZ175 physiology and virulence.由Pgf糖基化机制进行的翻译后修饰可调节变形链球菌OMZ175的生理特性和毒力。
Mol Microbiol. 2024 Aug;122(2):133-151. doi: 10.1111/mmi.15190. Epub 2023 Nov 16.
5
Identification and characterization of inulinases by bioinformatics analysis of bacterial glycoside hydrolases family 32 (GH32).通过对细菌糖苷水解酶家族32（GH32）进行生物信息学分析来鉴定和表征菊粉酶。
Eng Life Sci. 2023 Jul 9;23(8):e2300003. doi: 10.1002/elsc.202300003. eCollection 2023 Aug.
6
Structural and mechanistic studies of the N-glycosylation machinery: from lipid-linked oligosaccharide biosynthesis to glycan transfer.糖基化工程结构与机制研究：从脂连接寡糖生物合成到聚糖转移。
Glycobiology. 2023 Dec 25;33(11):861-872. doi: 10.1093/glycob/cwad053.
7
Legionella pneumophila-mediated host posttranslational modifications.军团菌属介导的宿主翻译后修饰。
J Mol Cell Biol. 2023 Nov 27;15(5). doi: 10.1093/jmcb/mjad032.
8
CRISPRi-Mediated Silencing of O-Linked Glycosylation Systems Enables the Depletion of Glycosylation Yet Results in Modest Proteome Impacts.CRISPRi 介导的 O-糖基化系统沉默能够消耗糖基化但导致适度的蛋白质组影响。
J Proteome Res. 2023 Jun 2;22(6):1762-1778. doi: 10.1021/acs.jproteome.2c00790. Epub 2023 Mar 30.
9
Platforms, advances, and technical challenges in virus-like particles-based vaccines.基于病毒样颗粒的疫苗的平台、进展和技术挑战。
Front Immunol. 2023 Feb 9;14:1123805. doi: 10.3389/fimmu.2023.1123805. eCollection 2023.
10
Clinical Value of Glycan Changes in Cerebrospinal Fluid for Evaluation of Post-Neurosurgical Bacterial Meningitis with Hemorrhagic Stroke Patients.脑脊液中聚糖变化对评估神经外科术后细菌性脑膜炎合并出血性卒中患者的临床价值
Diagnostics (Basel). 2023 Jan 4;13(2):187. doi: 10.3390/diagnostics13020187.
本文引用的文献
1
Diversity in the protein N-glycosylation pathways within the Campylobacter genus.弯曲杆菌属中蛋白质 N-糖基化途径的多样性。
Mol Cell Proteomics. 2012 Nov;11(11):1203-19. doi: 10.1074/mcp.M112.021519. Epub 2012 Aug 2.
2
Modification of the Campylobacter jejuni N-linked glycan by EptC protein-mediated addition of phosphoethanolamine.EptC 蛋白介导的磷酸乙醇胺添加修饰空肠弯曲菌 N-连接聚糖。
J Biol Chem. 2012 Aug 24;287(35):29384-96. doi: 10.1074/jbc.M112.380212. Epub 2012 Jul 2.
3
Characterization of two putative mechanosensitive channel proteins of Campylobacter jejuni involved in protection against osmotic downshock.鉴定弯曲杆菌中两种可能的机械敏感通道蛋白在渗透压休克保护中的作用。
Vet Microbiol. 2012 Nov 9;160(1-2):53-60. doi: 10.1016/j.vetmic.2012.04.044. Epub 2012 May 8.
4
An engineered eukaryotic protein glycosylation pathway in Escherichia coli.大肠杆菌中的工程化真核蛋白糖基化途径。
Nat Chem Biol. 2012 Mar 25;8(5):434-6. doi: 10.1038/nchembio.921.
5
Characterization of the structurally diverse N-linked glycans of Campylobacter species.弯曲杆菌属物种中结构多样的 N-连接聚糖的特征。
J Bacteriol. 2012 May;194(9):2355-62. doi: 10.1128/JB.00042-12. Epub 2012 Mar 2.
6
Systematic metabolic engineering for improvement of glycosylation efficiency in Escherichia coli.系统代谢工程提高大肠杆菌糖基化效率。
Biochem Biophys Res Commun. 2012 Mar 16;419(3):472-6. doi: 10.1016/j.bbrc.2012.02.020. Epub 2012 Feb 10.
7
Exploiting the Campylobacter jejuni protein glycosylation system for glycoengineering vaccines and diagnostic tools directed against brucellosis.利用空肠弯曲菌蛋白糖基化系统对布鲁氏菌病进行糖基工程疫苗和诊断工具的开发。
Microb Cell Fact. 2012 Jan 25;11:13. doi: 10.1186/1475-2859-11-13.
8
Novel protein substrates of the phospho-form modification system in Neisseria gonorrhoeae and their connection to O-linked protein glycosylation.淋病奈瑟菌磷酸化修饰系统的新型蛋白质底物及其与 O-连接糖蛋白糖基化的关系。
Infect Immun. 2012 Jan;80(1):22-30. doi: 10.1128/IAI.05920-11. Epub 2011 Nov 14.
9
Mechanisms and principles of N-linked protein glycosylation.N-连接蛋白糖基化的机制和原理。
Curr Opin Struct Biol. 2011 Oct;21(5):576-82. doi: 10.1016/j.sbi.2011.08.005.
10
Structural insights into the glycosyltransferase activity of the Actinobacillus pleuropneumoniae HMW1C-like protein.结构洞察胸膜肺炎放线杆菌 HMW1C 样蛋白的糖基转移酶活性。
J Biol Chem. 2011 Nov 4;286(44):38546-38557. doi: 10.1074/jbc.M111.237602. Epub 2011 Sep 9.
Zotero 插件