Unidad Monitorización de Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Ann Hepatol. 2012 May-Jun;11(3):356-63.
Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and the aim of our study was to evaluate its association with low-grade systemic inflammation.
A total of 4,077 patients clinically managed in the Cardiology, Hypertension, and Digestive Medicine Units were included in our study. Three subclinical chronic inflammatory degrees were established in accordance with the high-sensitivity C-reactive protein (hsCRP) concentrations proposed, for low (< 1 mg/L), average (1-3 mg/L), and high (> 3-10 mg/L) cardiovascular disease risk estimation.
In male patients with subclinical chronic inflammation and hsCRP concentrations < 1 mg/L, a significant positive correlation was observed between BChE and hsCRP (p < 0.02); however, for hsCRP concentrations > 3 mg/L, the correlation between these variables in both sexes becomes significantly negative (p < 0.001), as in patients with acute inflammation (hsCRP > 10 mg/L). In all cases significant positive correlations were obtained between the BChE activities and albumin concentrations (p < 0.001).
The liver production of BChE and albumin occurs in a coupled fashion, and these biochemical variables may be considered as negative inflammatory reactants, whose serum levels are inversely associated with the increasing degree of subclinical inflammation.
促炎细胞因子的产生可被乙酰胆碱（ACh）直接抑制，先前有研究报道，循环 ACh 水解能力总量与炎症反应之间存在关联。丁酰胆碱酯酶（BChE）是血浆中主要的 ACh 水解酶，我们的研究旨在评估其与低度全身性炎症的关系。
共纳入 4077 例在心脏病学、高血压和消化医学科接受临床治疗的患者。根据高敏 C 反应蛋白（hsCRP）浓度提出的建议，建立了三种亚临床慢性炎症程度：低（<1mg/L）、中（1-3mg/L）和高（>3-10mg/L）心血管疾病风险估计。
在亚临床慢性炎症且 hsCRP 浓度<1mg/L 的男性患者中，BChE 与 hsCRP 之间存在显著正相关（p<0.02）；然而，对于 hsCRP 浓度>3mg/L 的患者，两种性别之间这些变量之间的相关性显著为负（p<0.001），就像急性炎症（hsCRP>10mg/L）患者一样。在所有情况下，BChE 活性与白蛋白浓度之间均获得显著正相关（p<0.001）。
BChE 和白蛋白的肝脏产生是偶联的，这些生化变量可被视为负性炎症反应物，其血清水平与亚临床炎症程度的增加呈负相关。
