Ghafoori Mahyar, Shakiba Madjid, Seifmanesh Hamidreza, Hoseini Kamal
Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences , Tehran, Iran ; Department of Radiology, Hazrat Rasoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Radiol. 2012 Jun;9(2):67-70. doi: 10.5812/iranjradiol.7561. Epub 2012 Jun 30.
Infection after transrectal ultrasound (TRUS) guided biopsy of the prostate is a major and potentially life-threatening problem. Using antibiotic premedication can not completely eliminate infection after biopsy.
We performed this study to determine the value of using povidone-iodine in prevention of post biopsy infection.
Totally, 280 patients who were referred for TRUS guided biopsy of the prostate were divided randomly into two equal groups. The case group received an intrarectal mixture of povidone-iodine and lidocaine gel before performing biopsy, while the control group received only lidocaine gel. Patients were followed up for 30 days for possible signs of infection including fever, chills and dysuria.
The mean age in the case group was 68.7 ± 7 years and 68.1 ± 7 years in the control group (P = 0.78). Overall, there were signs and symptoms of infection in 78 patients (27.9%), of which 27 (19.3%) were in the case group, while 51 (36.4%) were in the control group (P = 0.001, OR = 2.4, 95% CI = 1.4-4.1).
Simple use of widely available povidone-iodine for cleaning the rectum before TRUS guided prostate biopsy can reduce the infection rate.
经直肠超声（TRUS）引导下前列腺穿刺活检后的感染是一个严重且可能危及生命的问题。使用抗生素进行预防性用药并不能完全消除活检后的感染。
我们开展本研究以确定聚维酮碘在预防活检后感染中的价值。
总共280例因TRUS引导下前列腺穿刺活检前来就诊的患者被随机分为两组，每组人数相等。病例组在进行活检前接受直肠内注入聚维酮碘和利多卡因凝胶的混合物，而对照组仅接受利多卡因凝胶。对患者进行30天的随访，观察是否有包括发热、寒战和排尿困难等感染迹象。
病例组的平均年龄为68.7±7岁，对照组为68.1±7岁（P = 0.78）。总体而言，78例患者（27.9%）出现感染的体征和症状，其中病例组有27例（19.3%），而对照组有51例（36.4%）（P = 0.001，OR = 2.4，95%可信区间 = 1.4 - 4.1）。
在TRUS引导下前列腺活检前，简单使用广泛可得的聚维酮碘清洁直肠可降低感染率。
