停用头孢呋辛酯治疗后发生的药物性线状IgA大疱性皮肤病。
Drug-induced linear IgA bullous dermatosis after discontinuation of cefuroxime axetil treatment.
作者信息
Pastuszczak Maciej, Lipko-Godlewska Sylwia, Jaworek Andrzej K, Wojas-Pelc Anna
机构信息
Jagiellonian University School of Medicine, Department of Dermatology, Cracow, Poland.
出版信息
J Dermatol Case Rep. 2012 Dec 31;6(4):117-9. doi: 10.3315/jdcr.2012.1119.
BACKGROUND
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune blistering disorder. The disease may be either idiopathic or druginduced. Over the past 30 years, approximately one hundred LABD cases have been described as induced by a wide range of drugs, chiefly antibiotics.
MAIN OBSERVATIONS
We report the case of 37-year-old woman who developed pruritic bullous lesions spread all over the body three weeks after her last dose of cefuroxime axetil. Antibiotic therapy was started due to rhino-sinusitis.
CONCLUSIONS
In most reported cases of drug-induced LABD, skin lesions occur within the time of drug administration. However, the onset of disease may be even after discontinuation of treatment. It seems that in such cases, other clinical conditions (like infection) act, as cofactors of immunologic response.
背景
线状免疫球蛋白A（IgA）大疱性皮肤病（LABD）是一种罕见的自身免疫性水疱病。该疾病可能是特发性的，也可能是药物诱导的。在过去30年中，约有100例LABD病例被描述为由多种药物诱发，主要是抗生素。
主要观察结果
我们报告了一名37岁女性的病例，她在最后一剂头孢呋辛酯三周后全身出现瘙痒性水疱性皮损。因鼻窦炎开始使用抗生素治疗。
结论
在大多数报告的药物诱导性LABD病例中，皮肤病变在用药期间出现。然而，疾病发作甚至可能在治疗停止后出现。在这种情况下，其他临床状况（如感染）似乎作为免疫反应的辅助因素起作用。
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