Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Drug Metab Rev. 2013 Feb;45(1):156-63. doi: 10.3109/03602532.2012.743561.
The constitutive androstane receptor (CAR, NR1I3) is a member of the nuclear receptor superfamily. Initially recognized as a xenobiotic receptor, CAR has been increasingly appreciated for its endobiotic functions in influencing glucose and lipid metabolism, whose dysregulations are implicated in the most prevalent metabolic disorders, such as obesity and type 2 diabetes. Given the metabolic benefits of CAR activation, CAR may represent an attractive therapeutic target to manage obesity and type 2 diabetes. Further studies are necessary to understand the mechanisms of action of CAR in metabolic diseases and to determine the human relevance of the antidiabetic effect of CAR.
组成型雄烷受体（CAR，NR1I3）是核受体超家族的一员。最初被认为是一种外源性受体，CAR 的内源性功能在影响葡萄糖和脂质代谢方面越来越受到重视，其失调与最常见的代谢紊乱有关，如肥胖和 2 型糖尿病。鉴于 CAR 激活的代谢益处，CAR 可能成为管理肥胖和 2 型糖尿病的有吸引力的治疗靶点。需要进一步研究来了解 CAR 在代谢疾病中的作用机制，并确定 CAR 的抗糖尿病作用对人类的相关性。
