Department of Dermatology, Yozgat State Hospital, Yozgat, Turkey.
Int J Dermatol. 2013 May;52(5):554-9. doi: 10.1111/j.1365-4632.2011.05424.x. Epub 2013 Jan 20.
Psoriasis is a chronic inflammatory disease affecting skin, nails, and joints. Although there are not many reports in the literature, ocular findings occur in approximately 10% of patients, in mostly those who have psoriatic arthritis. In this study, we aimed to evaluate eye involvement in psoriasis patients.
This study was performed on a total of 100 psoriasis patients and a group of 100 healthy individuals. History was taken from all study and control subjects, and dermatological, systemic, and ophthalmological examinations were performed and Schirmer and BUT values were measured. Constant variables were compared using the t-test, and categorical variables were compared using chi-square test. Relationship between ocular findings and sex, age, duration of psoriasis, PASI score, presence of psoriatic plaques on the eyelid, nail involvement, and psoriatic arthritis was evaluated using logistic regression analysis. Statistical analyses were performed individually for both right and left eyes.
The number of ocular findings in both eyes in the patient group was found to be statistically higher than that in the control group. Schirmer and BUT values were statistically lower in the patient group than those in the control group.
Although results of our study support the necessity of routine ophthalmological examination of psoriasis patients for early diagnosis and treatment, we believe that further studies are required on the etiopathogenesis of ocular involvement in psoriasis patients.
银屑病是一种影响皮肤、指甲和关节的慢性炎症性疾病。尽管文献中报道不多,但约 10%的患者会出现眼部表现,主要发生在患有银屑病关节炎的患者中。在这项研究中,我们旨在评估银屑病患者的眼部受累情况。
本研究共纳入 100 例银屑病患者和 100 例健康对照者。对所有研究对象和对照组均进行了病史采集,并进行了皮肤科、系统和眼科检查,测量了 Schirmer 和 BUT 值。使用 t 检验比较了常数变量,使用卡方检验比较了分类变量。使用逻辑回归分析评估了眼部表现与性别、年龄、银屑病病程、PASI 评分、眼睑银屑病斑块存在、指甲受累和银屑病关节炎之间的关系。对双眼分别进行了统计学分析。
发现患者组双眼的眼部表现数量明显高于对照组。与对照组相比,患者组的 Schirmer 和 BUT 值明显较低。
尽管我们的研究结果支持对银屑病患者进行常规眼科检查以早期诊断和治疗,但我们认为需要进一步研究银屑病患者眼部受累的发病机制。