Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Eur J Neurosci. 2013 Apr;37(8):1350-6. doi: 10.1111/ejn.12133. Epub 2013 Jan 21.
The organisation of timing in mammalian circadian clocks optimally coordinates behavior and physiology with daily environmental cycles. Chronic consumption of a high-fat diet alters circadian rhythms, but the acute effects on circadian organisation are unknown. To investigate the proximate effects of a high-fat diet on circadian physiology, we examined the phase relationship between central and peripheral clocks in mice fed a high-fat diet for 1 week. By 7 days, the phase of the liver rhythm was markedly advanced (by 5 h), whereas rhythms in other tissues were not affected. In addition, immediately upon consumption of a high-fat diet, the daily rhythm of eating behavior was altered. As the tissue rhythm of the suprachiasmatic nucleus was not affected by 1 week of high-fat diet consumption, the brain nuclei mediating the effect of a high-fat diet on eating behavior are likely to be downstream of the suprachiasmatic nucleus.
哺乳动物生物钟的时间组织最佳地协调了行为和生理与日常环境周期的关系。慢性高脂肪饮食会改变昼夜节律，但昼夜节律组织的急性影响尚不清楚。为了研究高脂肪饮食对生物钟生理学的直接影响，我们研究了高脂肪饮食喂养一周的小鼠中枢和外周时钟之间的相位关系。到第 7 天，肝脏节律的相位明显提前（提前 5 小时），而其他组织的节律不受影响。此外，一旦摄入高脂肪饮食，每日进食行为的节律就会发生改变。由于高脂肪饮食摄入 1 周并不影响视交叉上核的组织节律，因此介导高脂肪饮食对进食行为影响的大脑核可能位于视交叉上核的下游。
