Cedars-Sinai Medical Center, Los Angeles, CA, USA.
J Pediatr Surg. 2013 Jan;48(1):215-20. doi: 10.1016/j.jpedsurg.2012.10.041.
Our aim was to compare outcomes of children undergoing laparoscopic cholecystectomy with laparoscopic common bile duct exploration (LC+CBDE) to those undergoing laparoscopic cholecystectomy with adjunctive endoscopic retrograde cholangiopancreatography (LC+ERCP).
We performed a two-center retrospective chart review of all children (<18 years) undergoing LC+CBDE or LC+ERCP between January 2000 and July 2011. Wilcoxon test was performed on continuous variables and logistic regression modeling on categorical data. A P value < 0.05 was considered significant. Outcomes with a P value < 0.2 were selected for multivariable analysis.
Forty-two patients were identified. Twenty-four (57%) underwent LC+ERCP, and eighteen (43%) underwent LC+CBDE. Demographic and clinical factors were well matched between groups. Total operative time was similar between groups (157 min vs. 152 min, P = .26). LC+CBDE patients had zero major complications and five minor complications (retained stone: 3, pancreatitis: 1, late recurrence: 1). LC+ERCP patients experienced two major complications (duodenal perforation: 1, bleeding requiring transfusion: 1), and four minor complications (pancreatitis: 2, retained stone: 2, P = .57). Median length of stay was significantly longer (15.7 days vs. 6.6 days, P = .02), and median hospital cost was significantly higher ($18,132 vs. $12,735, P < .01) in the LC+ERCP group. Multivariable analysis revealed that cost was significantly lower in patients undergoing LC+CBDE (P = .05, OR= 0.71; 95% CI: 0.51-0.97).
LC+CBDE at the time of cholecystectomy is associated with decreased length of stay, decreased cost, and has similar or improved morbidity compared to LC+ERCP.
本研究旨在比较腹腔镜胆囊切除术联合腹腔镜胆总管探查术(LC+CBDE)与腹腔镜胆囊切除术联合内镜逆行胰胆管造影术(LC+ERCP)治疗儿童的效果。
我们对 2000 年 1 月至 2011 年 7 月期间在两个中心接受 LC+CBDE 或 LC+ERCP 的所有儿童(<18 岁)进行了回顾性图表分析。对连续变量进行 Wilcoxon 检验,对分类数据进行逻辑回归建模。P 值<0.05 被认为具有统计学意义。选择 P 值<0.2 的结果进行多变量分析。
共确定了 42 名患者。24 名(57%)患者接受了 LC+ERCP,18 名(43%)患者接受了 LC+CBDE。两组患者的人口统计学和临床因素相匹配。两组的总手术时间相似(157 分钟比 152 分钟,P=0.26)。LC+CBDE 组无重大并发症,5 例出现轻微并发症(结石残留:3 例,胰腺炎:1 例,迟发性复发:1 例)。LC+ERCP 组有 2 例出现重大并发症(十二指肠穿孔:1 例,出血需要输血:1 例)和 4 例轻微并发症(胰腺炎:2 例,结石残留:2 例,P=0.57)。LC+ERCP 组的中位住院时间明显延长(15.7 天比 6.6 天,P=0.02),中位住院费用明显增加(18132 美元比 12735 美元,P<0.01)。多变量分析显示,LC+CBDE 组的费用明显降低(P=0.05,OR=0.71;95%CI:0.51-0.97)。
与 LC+ERCP 相比,腹腔镜胆囊切除术联合腹腔镜胆总管探查术在胆囊切除术中具有住院时间短、费用低、发病率相似或降低的优势。