Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; Aging Research Center, Karolinska Institutet, Stockholm, Sweden; Alzheimer's Disease Research Center, Karolinska Institutet, Stockholm, Sweden.
Alzheimers Dement. 2013 Nov;9(6):657-65. doi: 10.1016/j.jalz.2012.09.012. Epub 2013 Jan 17.
Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland.
Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-intervention studies. Inclusion criteria are CAIDE Dementia Risk Score ≥6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures.
Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle-related factors are present, creating a window of opportunity for prevention. The intervention will be completed during 2014.
The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing intervention strategies to prevent or delay the onset of cognitive impairment and dementia.
芬兰认知障碍预防干预研究（FINGER）是一项正在芬兰进行的多中心、随机、对照试验。
参与者（1200 名认知能力下降风险者）是从以前的基于人群的非干预研究中招募的。入选标准为 CAIDE 痴呆风险评分≥6 分，以及认知表现处于平均水平或略低于预期年龄（但无明显损害），使用 Consortium to Establish a Registry for Alzheimer's Disease（CERAD）神经心理学成套测验评估。为期 2 年的多领域干预措施包括：营养指导；运动；认知训练和社会活动；以及代谢和血管风险因素的管理。对照组接受常规健康咨询。主要结局是认知表现，通过改良的神经心理学测验成套测验、Stroop 测验和 Trail Making 测验测量。主要次要结局是：痴呆（在延长随访后）；残疾；抑郁症状；血管风险因素和结局；生活质量；卫生资源的利用；以及神经影像学指标。
2009 年 9 月开始筛选，2011 年 12 月完成。所有 1200 人都已入组，按计划正在进行干预。基线临床特征表明，存在几种血管风险因素和与不健康生活方式相关的因素，为预防提供了机会之窗。干预将于 2014 年完成。
FINGER 处于国际合作努力的前沿，旨在解决早期识别处于晚年认知障碍风险增加的个体的临床和公共卫生问题，以及制定干预策略以预防或延迟认知障碍和痴呆的发生。
