Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí-UNIVALI, 88.302-202, Itajaí, Santa Catarina, Brazil.
J Ethnopharmacol. 2013 Mar 7;146(1):318-23. doi: 10.1016/j.jep.2012.12.052. Epub 2013 Jan 17.
Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant is well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in several ethno-medicines in tropical and subtropical countries.
This study was designed to evaluate the anti-hyperalgesic activity of corilagin using chemically and thermally based nociception models in mice.
Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice.
Corilagin presented activity in acetic acid model with the ID50 calculated value of 6.46 (3.09-13.51) being about 20.6 fold more potent than acetylsalicylic acid. It also exhibited activity against the first phase of formalin test with ID50 value of 18.38 (15.15-22.59) μmol/kg. In the capsaicin and glutamate models, corilagin demonstrated significant activity at the 3 mg/kg.
The experimental data demonstrated that corilagin exhibits anti-hyperalgesic activity that may be due to interaction with the glutamatergic system.
柯里拉京（β-1-O-没食子酰基-3,6-（R）-六氢二羟基二苯甲酰基-D-葡萄糖）是从叶下珠（大戟科）中分离出来的单宁。这种植物因其治疗多种与痛苦过程相关的疾病的功效而闻名，并且在热带和亚热带国家的几种民族医学中被使用。
本研究旨在使用化学和热伤害感受模型评估柯里拉京的抗痛觉过敏活性。
柯里拉京通过提取和色谱程序从叶下珠（大戟科）中分离出来，并用扭体、福尔马林、辣椒素、谷氨酸和热板试验在小鼠中评估抗痛觉过敏活性。
柯里拉京在醋酸模型中表现出活性，计算出的 ID50 值为 6.46（3.09-13.51），比乙酰水杨酸约强 20.6 倍。它还对福尔马林试验的第一阶段表现出活性，ID50 值为 18.38（15.15-22.59）μmol/kg。在辣椒素和谷氨酸模型中，柯里拉京在 3 mg/kg 时表现出显著的活性。
实验数据表明，柯里拉京表现出抗痛觉过敏活性，这可能是由于与谷氨酸能系统相互作用所致。
