Guerrero-Solano José Antonio, Jaramillo-Morales Osmar Antonio, Velázquez-González Claudia, De la O-Arciniega Minarda, Castañeda-Ovando Araceli, Betanzos-Cabrera Gabriel, Bautista Mirandeli
Academic Area of Pharmacy, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Mexico, San Agustin Tlaxiaca, Hidalgo 42160, Mexico.
Academic Area of Food Chemistry, Institute of Basic Sciences and Engineering, Autonomous University of the State of Hidalgo, Mexico, Pachuca- Tulancingo km 4.5 Carboneras, Pachuca de Soto, Hidalgo 42184, Mexico.
Plants (Basel). 2020 Mar 30;9(4):419. doi: 10.3390/plants9040419.
The use of complementary medicine has recently increased in an attempt to find effective alternative therapies that reduce the adverse effects of drugs. L. (pomegranate) has been used in traditional medicine for different kinds of pain. This review aims to explore the scientific evidence about the antinociceptive effect of pomegranate. A selection of original scientific articles that accomplished the inclusion criteria was carried out. It was found that different parts of pomegranate showed an antinociceptive effect; this effect can be due mainly by the presence of polyphenols, flavonoids, or fatty acids. It is suggested in the literature that the mechanisms of action may be related to the activation of the L-arginine / NO pathway, members of the TRP superfamily (TRPA1 or TRPV1) and the opioid system. The implications for the field are to know the mechanisms of action by which this effect is generated and thus be able to create alternative treatments for specific types of pain, which help alleviate it and reduce the adverse effects produced by drugs. The results propose that pomegranate and secondary metabolites could be considered in the treatment of inflammatory, nociceptive, and neuropathic pain.
为了寻找能减少药物不良反应的有效替代疗法，补充医学的使用近来有所增加。石榴已在传统医学中用于治疗各种疼痛。本综述旨在探究有关石榴抗伤害感受作用的科学证据。我们挑选了符合纳入标准的原始科学文章。研究发现，石榴的不同部位均显示出抗伤害感受作用；这种作用主要可能归因于多酚、黄酮类化合物或脂肪酸的存在。文献表明，其作用机制可能与L-精氨酸/一氧化氮途径、瞬时受体电位超家族（TRPA1或TRPV1）成员以及阿片样物质系统的激活有关。该领域的意义在于了解产生这种作用的机制，从而能够针对特定类型的疼痛开发替代疗法，以帮助缓解疼痛并减少药物产生的不良反应。研究结果表明，在治疗炎性疼痛、伤害感受性疼痛和神经性疼痛时可考虑使用石榴及其次生代谢产物。
