National Research Center for Geoanalysis (NRCGA), 26 Bai Wan Zhuang Avenue, Xicheng District, Beijing 100037, China.
Chemosphere. 2013 Apr;91(2):145-9. doi: 10.1016/j.chemosphere.2012.12.019. Epub 2013 Jan 18.
High concentration of hexachlorobenzene (HCB) was detected in Beijing breast milk in 2002. In order to identify trend in exposure, 65 breast milk samples were collected from 50 primiparous mothers during 2009-2011. The present concentration of HCB in the breast milk (range: 10.9-160.5 μg kg(-1) fat; median: 55.0 μg kg(-1) fat) was higher than that of the recent national average level and those of other countries or regions. This may be partially due to the previous extensive HCB exposure. A longitudinal study of HCB in human milk within six months postpartum showed that the level did not significantly decreased, and remained stable. The estimated daily intake (EDI) for the newborn (range: 0.045-0.43 μg kg(-1) body weight/d; median: 0.20 μg kg(-1) body weight/d) was also higher than the World Health Organization (WHO) tolerable daily intake value (0.17 μg kg(-1) body weight/d for non-cancer effects). Despite the apparent decrease of HCB body burden in past 10 years, the environmental health hazard from HCB contamination in Beijing remains a concern. Therefore a regular human milk monitoring programs for HCB are needed.
2002 年在北京母乳中检测到高浓度的六氯苯（HCB）。为了确定暴露趋势，于 2009-2011 年期间从 50 名初产妇中采集了 65 份母乳样本。目前母乳中 HCB 的浓度（范围：10.9-160.5μgkg(-1)脂肪；中位数：55.0μgkg(-1)脂肪）高于近期全国平均水平和其他国家或地区的水平。这可能部分是由于之前广泛的 HCB 暴露。对产后六个月内母乳中 HCB 的纵向研究表明，水平没有显著下降，并且保持稳定。新生儿的估计日摄入量（EDI）（范围：0.045-0.43μgkg(-1)体重/d；中位数：0.20μgkg(-1)体重/d）也高于世界卫生组织（WHO）可耐受日摄入量值（0.17μgkg(-1)体重/d 用于非癌症效应）。尽管过去 10 年 HCB 体内负荷明显下降，但北京 HCB 污染对环境健康的危害仍令人关注。因此，需要定期对 HCB 进行母乳监测。
