National Center for Scientific Research Demokritos, Patriarchou Grigoriou and Neapoleos Street, 15310 Aghia Paraskevi, Athens, Greece.
Curr Top Med Chem. 2012;12(23):2694-702. doi: 10.2174/1568026611212230007.
Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, since they combine the advantages of two different imaging modalities, namely SPECT or PET imaging with MR imaging. The benefit of such a combination is to more accurately interpret disease and abnormalities in vivo, by exploiting the advantages of each imaging technique, i.e. high sensitivity for SPECT/PET, high resolution anatomical information for MRI. In this review article, we provide an overview of recent findings in the synthesis, evaluation and application of radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI imaging probes.
双模态对比剂，如放射性标记的纳米粒子，是许多诊断应用的有前途的候选者，因为它们结合了两种不同成像模式的优点，即 SPECT 或 PET 成像与 MR 成像。这种组合的好处是通过利用每种成像技术的优势，更准确地解释体内疾病和异常，即 SPECT/PET 的高灵敏度，MRI 的高分辨率解剖信息。在这篇综述文章中，我们提供了关于合成、评估和应用放射性标记氧化铁纳米粒子作为双模态 SPECT/MRI 和 PET/MRI 成像探针的最新发现的概述。
