Henan Eye Institute, Zhengzhou, Henan Province, China.
Asian Pac J Trop Med. 2013 Feb;6(2):145-9. doi: 10.1016/S1995-7645(13)60011-5.
To explore the effect of Salvia miltiorrhiza on diabetic retinopathy (DR).
Diabetic mice of natural incidence type with monogenic inheritance were selected. Alloxan was injected into the caudal vein of mice once to induce DR. The structural changes of retina tissue in normal mice, DR mice and mice with high, medium and low dose of Salvia miltiorrhiza injection were observed under microscope. Then the blood glucose concentration and malonaldehyde (MDA) content were detected.
There were some microaneurysms in retina of DR group, number of gangliocyte was decreased significantly, and cells were sparse and in disorder. After modeling, the blood glucose level of high-dose Salvia miltiorrhiza group (SM III group) was significantly different from DR group (P<0.01). Till the tenth week, the blood glucose level of all SM groups was decreased significantly compared with DR group (P<0.01). The effective rates of three SM groups were 93.8%, 76.4% and 50.3%, respectively. After ten weeks, MDA content of DR group was significantly higher than those of the normal control group and SM group (P<0.01), and medium and low dose SM groups had significantly higher MDA than that of normal control group (P<0.01).
Salvia miltiorrhiza had certain protective effect on DR mice through the blood-ocular barrier.
探讨丹参对糖尿病视网膜病变（DR）的作用。
选择自然发病型单基因遗传糖尿病小鼠。尾静脉一次性注射链脲佐菌素（STZ）诱导 DR 模型。观察正常小鼠、DR 小鼠及丹参高、中、低剂量组小鼠视网膜组织的结构变化，检测各组小鼠血糖浓度和丙二醛（MDA）含量。
DR 组小鼠视网膜可见微动脉瘤，神经节细胞数明显减少，细胞稀疏排列紊乱。丹参高剂量组（SM III 组）小鼠造模后血糖水平与 DR 组比较差异有统计学意义（P<0.01），各 SM 组至第 10 周时血糖水平均明显低于 DR 组（P<0.01），SM 三组有效率分别为 93.8%、76.4%和 50.3%。DR 组 MDA 含量明显高于正常对照组和 SM 组（P<0.01），中、低剂量 SM 组 MDA 含量明显高于正常对照组（P<0.01）。
丹参通过血眼屏障对 DR 小鼠有一定的保护作用。
