Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Cell Mol Life Sci. 2013 Oct;70(19):3513-24. doi: 10.1007/s00018-012-1256-2. Epub 2013 Jan 23.
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the diverse functions of the complex. In this review, we examine the structures and biological roles of the NuRD subunits and discuss new avenues of research to advance our understanding of the NuRD-mediated signaling network.
核小体重塑和去乙酰化酶(NuRD)复合物调节染色质组织、基因转录、基因组稳定性和发育信号转导。NuRD 具有独特的双重酶活性,其六个核心亚基中包含一个 ATP 酶和一个组蛋白去乙酰化酶。最近的研究表明,NuRD 的组成和亚基之间的相互作用可能决定了该复合物的多种功能。在这篇综述中,我们检查了 NuRD 亚基的结构和生物学作用,并讨论了新的研究途径,以推进我们对 NuRD 介导的信号网络的理解。