NuRD 与多能性：复杂的平衡行为。
NuRD and pluripotency: a complex balancing act.
机构信息
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
出版信息
Cell Stem Cell. 2012 May 4;10(5):497-503. doi: 10.1016/j.stem.2012.04.011.
Abstract
Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.
摘要
胚胎干细胞（ESCs）的定义有两个重要特征——多能性和自我更新——其平衡需要信号转导途径、转录因子网络和表观遗传调节剂的协同作用。最近的研究结果表明，NuRD 染色质重塑复合物参与了 ESC 调节途径的复杂编排。
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