松果抗肿瘤物质对流感病毒感染的抑制作用。

Inhibition of influenza virus infection by pine cone antitumor substances.

作者信息

Nagata K, Sakagami H, Harada H, Nonoyama M, Ishihama A, Konno K

机构信息

Department of Molecular Genetics, National Institute of Genetics, Shizuoka, Japan.

出版信息

Antiviral Res. 1990 Jan;13(1):11-21. doi: 10.1016/0166-3542(90)90041-5.

DOI:10.1016/0166-3542(90)90041-5

PMID:2334167

Abstract

The anti-influenza virus activity of polysaccharides and other high molecular weight fractions from pine cone extract (PCE) of Pinus parviflora Sieb. et Zucc. was investigated. None of the fractions affected the growth of MDCK cells. The acidic PCE substances markedly suppressed the growth of the influenza virus in MDCK cells. Significant inhibition of both the viral protein synthesis in infected cells and virion-associated RNA-dependent RNA polymerase activity was observed with these acidic fractions. Although amantadine inhibited virus plaque formation as effectively as PCE fractions, it was less effective in inhibiting the RNA polymerase activity. These results suggest that PCE, which has been shown to contain antitumor substance(s), also contains anti-influenza virus substance(s).

摘要

对赤松松果提取物（PCE）中的多糖和其他高分子量组分的抗流感病毒活性进行了研究。这些组分均未影响MDCK细胞的生长。酸性PCE物质显著抑制了MDCK细胞中流感病毒的生长。用这些酸性组分观察到受感染细胞中的病毒蛋白合成以及病毒粒子相关的RNA依赖性RNA聚合酶活性均受到显著抑制。虽然金刚烷胺抑制病毒蚀斑形成的效果与PCE组分一样有效，但在抑制RNA聚合酶活性方面效果较差。这些结果表明，已证明含有抗肿瘤物质的PCE也含有抗流感病毒物质。