血清和脑脊液麻疹抗体水平在多发性硬化症或临床孤立综合征患者中随时间增加。
Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome.
机构信息
Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
出版信息
J Neuroimmunol. 2012 Jun 15;247(1-2):70-4. doi: 10.1016/j.jneuroim.2012.03.014. Epub 2012 Apr 11.
In general, measles virus (MV) immunoglobulin G (IgG) antibody titres decline over time. However, we found that serum and CSF MV antibody titres increased with age (slope=0.038, p<0.001 and slope=0.022, p=0.008), respectively, and disease duration (slope=0.031, p=0.002 and slope=0.032, p=0.005), respectively, in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). The age dependency of serum antibody levels differed between patients and controls (slope=0.038 versus -0.004, p<0.001). The increasing MV antibody titres over time in MS/CIS patients support a general nonspecific stimulation of B cells and plasma cells that is not confined only to the CNS/CSF compartment.
一般来说，麻疹病毒（MV）免疫球蛋白 G（IgG）抗体效价随时间下降。然而，我们发现血清和脑脊液 MV 抗体效价随年龄（斜率=0.038，p<0.001 和斜率=0.022，p=0.008）分别增加，以及疾病持续时间（斜率=0.031，p=0.002 和斜率=0.032，p=0.005），分别在多发性硬化症（MS）或临床孤立综合征（CIS）患者中。血清抗体水平的年龄依赖性在患者和对照组之间存在差异（斜率=0.038 与 -0.004，p<0.001）。MS/CIS 患者的 MV 抗体效价随时间的增加支持 B 细胞和浆细胞的一般非特异性刺激，而不仅仅局限于 CNS/CSF 隔室。
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