Pulitzer D R, Martin P C, Collins P C, Reitmeyer W J
Department of Pathology, Tulane University School of Medicine, New Orleans, La 70112.
Arch Pathol Lab Med. 1990 May;114(5):482-4.
We report a histologically distinctive form of small blood vessel calcification that led to necrosis and ulceration of the skin. Microscopically, wedge-shaped ulcers of the skin and superficial subcutis were observed. Calcified deposits were identified in the walls of small blood vessels at the ulcer bases. Recanalized thrombi occluded the lumina of some of the calcified vessels. On the basis of these distinctive histologic findings, hyperparathyroidism was accurately predicted. These changes have previously been cited in the internal medicine and dermatology literature but, to our knowledge, not in the pathology literature. We believe that these lesions are not rare and are probably often overlooked by pathologists. The histologic and clinical findings in two cases are presented.
我们报告了一种组织学上独特的小血管钙化形式，其导致了皮肤坏死和溃疡。显微镜下，观察到皮肤和浅表皮下组织呈楔形溃疡。在溃疡底部的小血管壁中发现了钙化沉积物。再通的血栓阻塞了一些钙化血管的管腔。基于这些独特的组织学发现，准确预测了甲状旁腺功能亢进。这些变化先前已在内科和皮肤科文献中被提及，但据我们所知，病理学文献中尚未见报道。我们认为这些病变并不罕见，可能常被病理学家忽视。本文介绍了两例病例的组织学和临床发现。
