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[钙化性擦烂红斑,皮肤钙化的罕见原因]

[Calcified intertrigo, a rare cause of cutaneous calcinosis].

作者信息

Benkalfate L, Zein K, le Gall F, Chevrant-Breton J, Rivalan J, le Pogamp P

机构信息

Service de Dermatologie, CHU Pontchaillou, Rennes.

出版信息

Ann Dermatol Venereol. 1995;122(11-12):789-92.

PMID:8729828
Abstract

INTRODUCTION

Calcinosis cutis is classically described in patients presenting chronic renal failure with secondary hyperparathyroidism. There are three clinical types described in the literature: cutaneous necrosis (secondary to vascular calcification), panniculitis with calcification of the adipose tissue and necrosis of the skin and dermo-hypodermic calcinosis without necrosis usually called metastatic calcinosis. The latter can affect all tissues but skin involvement is rare.

CASE REPORT

A case of calcinosis cutis is presented in a 50 years old woman with moderate secondary hyperparathyroidism and chronic renal failure caused by renal amyloidosis. She was referred by the renal unit to our service for erythematous, woody-hard, infiltrated plaques with petechial purpura satellite lesions, involving the flexural areas, that appeared within a few weeks.

DISCUSSION

This observation is original by the topography of the cutaneous lesions the involvement of the fexural areas is unusual and by the histologic aspect of pseudoxanthome elastic-like. We must notice that the hyperparathyroidism had always been very moderate (normal parathormonemia) compared to the rapid development of an important dermic calcinosis.

摘要

引言

皮肤钙质沉着症在患有慢性肾衰竭并伴有继发性甲状旁腺功能亢进的患者中经典描述。文献中描述了三种临床类型:皮肤坏死(继发于血管钙化)、脂肪组织钙化的脂膜炎以及皮肤和真皮 - 皮下钙质沉着症且无坏死(通常称为转移性钙质沉着症)。后者可累及所有组织,但皮肤受累罕见。

病例报告

一名50岁女性出现皮肤钙质沉着症,患有中度继发性甲状旁腺功能亢进及由肾淀粉样变性引起的慢性肾衰竭。她由肾科转至我们科室,数周内出现红斑、木质样硬、浸润性斑块,伴有瘀点性紫癜卫星状损害,累及屈侧部位。

讨论

该病例的独特之处在于皮肤病变的部位(屈侧部位受累不常见)以及组织学上类似弹性假黄瘤样表现。我们必须注意到,与重要的皮肤钙质沉着症快速发展相比,甲状旁腺功能亢进一直非常轻微(甲状旁腺素血症正常)。

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