International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, 69372 Cedex 08, France.
Infect Agent Cancer. 2013 Jan 23;8(1):4. doi: 10.1186/1750-9378-8-4.
Only a small portion of HPV 16 infections persist and can lead to cervical intraepithelial lesions and cancer. Factors that favour HPV persistence versus clearance are still poorly understood, but several studies have suggested that HPV intra-type variants may influence persistence and clinical outcome. The aim of this study was to assess the possible association between HPV 16 variants and the risk for viral persistence in the general population of France.
One hundred and forty two women infected with HPV 16 with normal cytology, without previous treatment for cervical lesions, and with a valid second follow-up visit 4 to 16 months later, were selected from patients participating in routine cervical cancer screening in the Reims HPV Primary Screening Cohort Study. HPV intra-type variants were determined by sequencing the HPV 16 E6 open reading frame, and were compared for viral persistence at the second visit using odds ratios (OR) to estimate relative risk.
Although no statistically significant differences in risk for persistence were observed by the HPV 16 variant lineage, European variants containing the polymorphism 350 T (EUR-350 T) appeared to persist more often than those containing 350 G (EUR-350 G) (OR = 1.6, 95% CI = 0.8-3.4).
No strong differences were observed in the risk of viral persistence for the HPV 16 variants that predominate in France.
只有一小部分 HPV 16 感染会持续存在，并可能导致宫颈上皮内病变和癌症。有利于 HPV 持续存在而不是清除的因素仍知之甚少，但有几项研究表明，HPV 同型变体可能影响持续性和临床结果。本研究旨在评估 HPV 16 变体与法国普通人群中病毒持续性的风险之间的可能关联。
从参加兰斯 HPV 初级筛查队列研究的常规宫颈癌筛查患者中，选择了 142 名感染 HPV 16 且细胞学正常、无宫颈病变既往治疗史且在 4 至 16 个月后有有效第二次随访的女性。通过 HPV 16 E6 开放阅读框的测序确定 HPV 16 同型变体，并使用比值比（OR）估计相对风险来比较第二次就诊时的病毒持续性。
尽管 HPV 16 变体谱系没有观察到持续性风险的统计学显著差异，但含有多态性 350T（EUR-350T）的欧洲变体似乎比含有 350G（EUR-350G）的变体更常持续存在（OR=1.6，95%CI=0.8-3.4）。
在法国占主导地位的 HPV 16 变体中，病毒持续性的风险没有明显差异。
