Grodzki Martha, Besson Guillaume, Clavel Christine, Arslan Annie, Franceschi Silvia, Birembaut Philippe, Tommasino Massimo, Zehbe Ingeborg
Johannes Gutenberg University, Medical Microbiology, Mainz, Germany.
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):820-2. doi: 10.1158/1055-9965.EPI-05-0864.
To test the significance of human papillomavirus (HPV) type 16 and HPV16 E6 variants as risk factors for viral persistence and progression to high-grade lesion, we did a nested case-control study within a cohort study of >15,000 Caucasian French women. Three groups infected with high-risk HPV were compared: (a) women with cleared infection (controls, n = 201), (b) women with persistent infection (cases, n = 87), and (c) women who progressed into high-grade lesion (cases, n = 58). Women with persistent HPV infection and those that progressed into high-grade lesions were likelier to harbor HPV16 than other high-risk HPV types [odds ratio (OR), 2.4; 95% confidence interval (95% CI), 1.3-4.3 and OR, 4.2; 95% CI, 2.2-8.1, respectively]. Notably, especially elevated ORs of persistence (3.0; 95% CI, 1.4-6.7) and progression (6.2; 95% CI, 2.7-14.3) were found among women who harbored the HPV16 350G variant. Thus, HPV type and HPV16 variant seem to be risk factors for viral persistence and progression of infections into high-grade cervical lesions.
为了检验人乳头瘤病毒16型（HPV16）及其E6变体作为病毒持续感染和进展为高级别病变风险因素的显著性，我们在一项针对超过15,000名法国白人女性的队列研究中开展了一项巢式病例对照研究。比较了三组高危型HPV感染者：（a）感染已清除的女性（对照组，n = 201），（b）持续感染的女性（病例组，n = 87），以及（c）进展为高级别病变的女性（病例组，n = 58）。与其他高危型HPV相比，持续感染HPV的女性和进展为高级别病变的女性更有可能感染HPV16[比值比（OR）分别为2.4；95%置信区间（95%CI）为1.3 - 4.3和OR为4.2；95%CI为2.2 - 8.1]。值得注意的是，在携带HPV16 350G变体的女性中，持续感染（3.0；95%CI为1.4 - 6.7）和进展（6.2；95%CI为2.7 - 14.3）的OR值尤其升高。因此，HPV型别和HPV16变体似乎是病毒持续感染以及感染进展为高级别宫颈病变的风险因素。
