Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Molecules. 2012 Dec 21;18(1):128-39. doi: 10.3390/molecules18010128.
Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC(50)value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC(50) of 0.207 µM.
从龙血树科龙血树属植物斜叶龙血树的茎皮中分离得到 11 个化合物：岗尼辛 A（1）、岗尼辛 B（2）、岗尼辛 C（3）、岗尼辛 D（4）、塔皮奥丁（5）、龙血素（6）、9-去氧岗波吡喃酮（7）、翼萼木醇（8）、柳叶木兰碱（9）、苯甲酰胺（10）和肉桂酸（11）。所有化合物均通过光谱分析鉴定，对于已知化合物，通过与已发表的数据进行比较进行鉴定。龙血素（6）对结肠癌细胞系（HT-29）表现出温和的细胞毒性，IC50 值为 64.17±5.60μM。在所有测试的化合物中，岗尼辛 B（2）在 DPPH 测定中表现出最高的抗氧化活性，IC50 为 0.207μM。
