Chandgude Ajay L, Narducci Daniele, Kurpiewska Katarzyna, Kalinowska-Tłuścik Justyna, Dömling Alexander
Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Jagiellonian University, Faculty of Chemistry, Department of Crystal Chemistry and Crystal Physics Biocrystallography Group, Ingardena 3, 30-060 Krakow, Poland.
RSC Adv. 2017;7(79):49995-49998. doi: 10.1039/C7RA07392E. Epub 2017 Oct 26.
A diastereoselective one pot five-component reaction toward the synthesis of 4-(tetrazole)-1,3-oxazinanes has been reported. The sonication-accelerated, catalyst-free, simple, general and highly time efficient, Asinger-Ugi-tetrazole reaction was used for the synthesis of diverse 4-(tetrazole)-1,3-oxazinanes. The reaction exhibit excellent diastereoselectivity and broad substrate scope.
据报道，一种用于合成4-(四唑)-1,3-恶嗪烷的非对映选择性一锅五组分反应。采用超声加速、无催化剂、简单、通用且高度省时的阿辛格-乌吉-四唑反应来合成多种4-(四唑)-1,3-恶嗪烷。该反应具有优异的非对映选择性和广泛的底物范围。
