显微镜结肠炎的流行病学危险因素：一项前瞻性病例对照研究。
Epidemiological risk factors in microscopic colitis: a prospective case-control study.
机构信息
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Spain.
出版信息
Inflamm Bowel Dis. 2013 Feb;19(2):411-7. doi: 10.1002/ibd.23009.
BACKGROUND
The cause of collagenous colitis (CC) and lymphocytic colitis (LC) is unknown and epidemiological risk factors for CC and LC are not well studied. The aim was to evaluate in a case-control study epidemiological risk factors for CC and LC.
METHODS
In all, 120 patients with CC, 70 with CL, and 128 controls were included. For all cases and controls information was prospectively recorded. A binary logistic regression analysis was performed separately for CC and LC.
RESULTS
Independent associations observed with the diagnosis of CC were: current smoking (odds ratio [OR], 2.4), history of polyarthritis (OR, 20.8), and consumption of lansoprazole (OR, 6.4), low-dose aspirin (OR, 3.8), beta-blockers (OR, 3.6), and angiotensin II receptor antagonists (OR 0.20). In the case of LC they were: current smoking (OR, 3.8), associated autoimmune diseases (OR, 8), and consumption of sertraline (OR, 17.5), omeprazole (OR 2.7), low-dose aspirin (OR, 4.7), and oral antidiabetic drugs (OR, 0.14).
CONCLUSIONS
The consumption of drugs, current smoking, and associated autoimmune diseases were independently associated with the risk of microscopic colitis.
背景
胶原性结肠炎（CC）和淋巴细胞性结肠炎（LC）的病因尚不清楚，CC 和 LC 的流行病学危险因素也尚未得到很好的研究。目的是在病例对照研究中评估 CC 和 LC 的流行病学危险因素。
方法
共纳入 120 例 CC 患者、70 例 CL 患者和 128 例对照者。所有病例和对照者的资料均前瞻性记录。对 CC 和 LC 分别进行二项逻辑回归分析。
结果
与 CC 诊断相关的独立关联因素为：当前吸烟（比值比[OR]，2.4）、多关节炎病史（OR，20.8）和使用兰索拉唑（OR，6.4）、低剂量阿司匹林（OR，3.8）、β受体阻滞剂（OR，3.6）和血管紧张素 II 受体拮抗剂（OR，0.20）。对于 LC，相关因素为：当前吸烟（OR，3.8）、相关自身免疫性疾病（OR，8）、舍曲林（OR，17.5）、奥美拉唑（OR，2.7）、低剂量阿司匹林（OR，4.7）和口服降糖药（OR，0.14）。
结论
药物使用、当前吸烟和相关自身免疫性疾病与显微镜下结肠炎的风险独立相关。
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