Fares Eddy, El Hajj Weam, Nahon Stéphane, Macaigne Gilles
Department of Gastroenterology, Intercommunal Hospital Center Le Raincy Montfermeil, Montfermeil, France.
Gastro Hep Adv. 2024 Sep 19;4(2):100554. doi: 10.1016/j.gastha.2024.09.009. eCollection 2025.
We report the first case of collagenous colitis attributed to perindopril use, in a 90-year-old woman. The patient developed diarrhea with hypokalemia, 3 weeks after perindopril was introduced in her medications for uncontrolled hypertension. Significant thickening of the basal epithelial membrane (up to 80 μm) was found on random colon biopsies. Diarrhea resolved within 3 days after perindopril withdrawal. Four months later, left colon biopsies revealed a normalization of the basal membrane thickness. The intrinsic imputability of perindopril as the causative agent of microscopic colitis is considered to be reasonable by the French accountability technique. There was no rechallenge test conducted.
我们报告了首例因使用培哚普利导致胶原性结肠炎的病例，患者为一名90岁女性。该患者在因高血压控制不佳开始服用培哚普利3周后，出现腹泻伴低钾血症。随机结肠活检发现基底上皮膜显著增厚（达80μm）。停用培哚普利后3天内腹泻缓解。4个月后，左半结肠活检显示基底膜厚度恢复正常。根据法国的因果关系判定技术，培哚普利作为显微镜下结肠炎病因的内在因果关系被认为是合理的。未进行再激发试验。
