Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Pharm Res. 2013 Apr;30(4):915-31. doi: 10.1007/s11095-013-0971-1. Epub 2013 Jan 24.
With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, the main disease targets for the local delivery of siRNA to specific tissues or organs, including the skin, the lung, the eye, the nervous system, the digestive system and the vagina, were explored.
随着越来越多的研究提出新的和最佳的递送策略，通过局部给予 siRNA 来有效沉默与基因相关的疾病，本综述旨在广泛概述用于局部给予的非病毒 siRNA 递送系统的最重要和最新进展。此外，还探讨了局部给予 siRNA 到特定组织或器官的主要疾病靶标，包括皮肤、肺、眼睛、神经系统、消化系统和阴道。
