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大面积肺栓塞与血栓形成倾向

Massive pulmonary embolism and thrombophilia.

作者信息

Qureshi Iman, Meshaka Riwa, Donohue Claire, Ali Asad

机构信息

University Hospital Coventry and Warwickshire, Coventry, UK.

出版信息

BMJ Case Rep. 2013 Jan 22;2013:bcr2012008197. doi: 10.1136/bcr-2012-008197.

DOI:10.1136/bcr-2012-008197
PMID:23345503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3604493/
Abstract

A 32-year-old man presented overnight to the accident and emergency unit with mild breathlessness on exertion. He was found to be hypoxic on room air and his chest x-ray revealed areas of patchy lung consolidation. He was given intravenous antibiotics for presumed community-acquired pneumonia. Unfortunately his condition deteriorated and he remained significantly hypoxic despite high-flow oxygen with ECG evidence of right heart strain. Further questioning revealed a history of protein S deficiency and a strong family history of venous thromboembolic disease. An urgent CT pulmonary angiogram showed an evidence of massive pulmonary embolism and the patient was successfully thrombolysed.

摘要

一名32岁男性夜间因活动时轻度气促前往急诊室。在室内空气中发现他存在低氧血症,胸部X线显示肺部有斑片状实变区域。考虑为社区获得性肺炎,给予其静脉注射抗生素。不幸的是,他的病情恶化,尽管给予高流量氧气治疗,他仍严重缺氧,心电图显示有右心劳损迹象。进一步询问发现他有蛋白S缺乏病史,且有静脉血栓栓塞性疾病的家族史。紧急CT肺动脉造影显示有大面积肺栓塞的证据,该患者成功接受了溶栓治疗。

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本文引用的文献

1
Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC).急性肺栓塞诊断与管理指南:欧洲心脏病学会(ESC)急性肺栓塞诊断与管理特别工作组
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Hereditary thrombophilia.遗传性血栓形成倾向
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A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state.3788名健康志愿者的蛋白S抗原水平研究:年龄、性别和激素使用的影响以及缺乏状态患病率的估计
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Massive acute pulmonary embolism in protein S deficiency--a case report.蛋白S缺乏症所致的大面积急性肺栓塞——病例报告
Ann Acad Med Singap. 1994 May;23(3):396-9.
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Thrombolysis in pulmonary embolism: an adolescent with protein S deficiency.
J Am Board Fam Pract. 1994 Nov-Dec;7(6):523-5.