Aslanidi O V, Mornev O A
Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, Pushchino, Moscow Region, 142292 Russia.
J Biol Phys. 1999 Jun;25(2-3):149-64. doi: 10.1023/A:1005119218136.
On the basis of numerical simulations of the partial McAllister-Noble-Tsien equations quantitatively describing the dynamics of electrical processes in conductive cardiac Purkinje fibers we reveal unusual - soliton-like - regimes of interaction of nonlinear excitation pulses governing the heart contraction rhythm: reflection of colliding pulses instead of their annihilation. The phenomenological mechanism of the reflection effects is that in a narrow (but finite) range of the system parameters the traveling pulse presents a doublet consisting of a high-amplitude leader followed by a low-amplitude subthreshold wave. Upon collisions of pulses the leaders are annihilated, but subthreshold waves summarize becoming superthreshold and initiating two novel echo-pulses traveling in opposite directions. The phenomenon revealed presents an analogy to the effect of reflection of colliding nerve pulses, predicted recently, and can be of use in getting insight into the mechanisms of heart rhythm disturbances.
基于对部分麦卡利斯特 - 诺布尔 - 钱方程的数值模拟，这些方程定量描述了心脏传导性浦肯野纤维中电过程的动力学，我们揭示了控制心脏收缩节律的非线性激发脉冲相互作用的异常——类孤子——状态：碰撞脉冲的反射而非湮灭。反射效应的唯象机制是，在系统参数的狭窄（但有限）范围内，传播脉冲呈现为由高幅先导波后跟低幅阈下波组成的双峰。脉冲碰撞时，先导波湮灭，但阈下波叠加后变为超阈，并引发两个沿相反方向传播的新回波脉冲。所揭示的现象类似于最近预测的碰撞神经脉冲的反射效应，可用于深入了解心律紊乱的机制。
