Larson B, Silfverswärd C, Nilsson B, Pettersson F
Department of Obstetrics and Gynecology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1990;29(2):185-91. doi: 10.3109/02841869009126543.
One hundred and forty-three patients with uterine leiomyosarcomas treated at Radiumhemmet from 1936 through 1981 were reviewed. Clinical and histopathological findings were analysed by bivariate and multivariate analyses to assign prognostic factors. Mitotic count, menopausal status and stage showed to be significant predictors of survival. The series was divided into two periods of time and a significantly higher survival rate in the second period was noted for patients with stage I disease. Thirty-seven patients with tumors showing less than 10 mitotic figures per 10 high power fields had a 5-year survival rate of 65% compared with 17% for 106 patients with 10 or more mitotic figures per 10 high power field. No significant predictor of a bad outcome for these low mitotic count tumors was found.
回顾了1936年至1981年在镭疗医院接受治疗的143例子宫平滑肌肉瘤患者。通过双变量和多变量分析对临床和组织病理学结果进行分析，以确定预后因素。有丝分裂计数、绝经状态和分期显示为生存的重要预测因素。该系列被分为两个时间段，第一期疾病患者在第二个时间段的生存率显著更高。37例每10个高倍视野有丝分裂数少于10个的肿瘤患者的5年生存率为65%，而106例每10个高倍视野有丝分裂数为10个或更多的患者的5年生存率为17%。未发现这些低有丝分裂计数肿瘤预后不良的显著预测因素。
