McKeag Sean, McInnes Elizabeth F
Huntingdon Life Sciences, Woolley Road, Alconbury, Cambs, PE328 4HS, U. K. ; Covance Laboratories, Otley Road, Harrogate, North Yorkshire, HG3 1PY, U. K.
J Toxicol Pathol. 2012 Dec;25(4):249-56. doi: 10.1293/tox.25.249. Epub 2012 Dec 20.
Lymphoplasmacytic gastritis is a concern for toxicological pathologists reading preclinical, non-human primate toxicity studies because subtle gastric changes which could be treatment-related may be masked and gastritis lesions may be confused with treatment-related effects and thus a gastric finding may be incorrectly assigned as a treatment-related lesion. This paper discusses the incidence of lymphoplasmacytic gastritis in cynomolgus monkeys at a contract research organization. The incidence of lymphoplasmacytic gastritis in the fundus and antrum of control cynomolgus monkeys on 18 non-gastric compound studies, was scored. The average fundus score ranged from 0.3 to 1.5 and the average antral score ranged from 0.9 to 3.5 in the cynomolgus monkey stomachs examined. The number of affected control animals in a study ranged from 0 to 5 control animals. No correlation between the route of vehicle administration and the severity or incidence of the lesions was noted. The percentage incidence of affected animals ranged from 0 to 100%. An increased incidence lymphoplasmatic gastritis from 2000 to 2004 was noted. The implications of lymphoplasmacytic gastritis in cynomolgus monkeys used for acute toxicity studies are discussed.
淋巴浆细胞性胃炎是毒理病理学家在解读临床前非人类灵长类动物毒性研究时所关注的问题，因为可能与治疗相关的细微胃部变化可能会被掩盖，胃炎病变可能会与治疗相关效应相混淆，从而导致胃部发现被错误地判定为与治疗相关的病变。本文讨论了一家合同研究机构中食蟹猴淋巴浆细胞性胃炎的发病率。对18项非胃部化合物研究中对照食蟹猴胃底和胃窦的淋巴浆细胞性胃炎发病率进行了评分。在所检查的食蟹猴胃中，胃底平均评分在0.3至1.5之间，胃窦平均评分在0.9至3.5之间。一项研究中受影响的对照动物数量在0至5只对照动物之间。未观察到赋形剂给药途径与病变严重程度或发病率之间的相关性。受影响动物的发病率百分比在0至100%之间。注意到2000年至2004年淋巴浆细胞性胃炎的发病率有所增加。本文还讨论了食蟹猴在急性毒性研究中出现淋巴浆细胞性胃炎的影响。
