东莨菪亭等抗炎二萜类化合物来源于越南巴豆。

Anti-inflammatory diterpenoids from Croton tonkinensis.

机构信息

Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, Republic of China.

出版信息

J Nat Prod. 2013 Feb 22;76(2):230-6. doi: 10.1021/np300699f. Epub 2013 Jan 24.

Abstract

Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.

摘要

从越南巴豆的甲醇提取物中分离得到了两个已知的贝壳杉烷（1、2），八个新的贝壳杉烷（3-10），以及 16 个已知的贝壳杉烷型二萜（12-27）。此外，通过比较其物理和光谱数据与报道的数据，鉴定了 30 个已知化合物。在所分离的化合物中，ent-18-乙酰氧基贝壳杉-16-烯-15-酮（20）对超氧阴离子生成和弹性蛋白酶释放的抑制作用最为显著。