Department of Ophthalmology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.
Acta Ophthalmol. 2013 Feb;91(1):e56-63. doi: 10.1111/j.1755-3768.2012.02562.x.
To compile a multicenter normative database of retinal nerve fibre layer (RNFL) and macular thicknesses and macular volume values in healthy Caucasian children 4-17 years using spectral-domain optical coherence tomography (SD-OCT). To analyse variations in the OCT measurements as a function of age, sex, refraction, and axial length (AL).
An observational, multicenter and cross-sectional study among 301 healthy Caucasian children recruited at three Spanish centres was performed. To compile the database, each child underwent a dilated eye examination and a cycloplegic refraction, five AL measurements (IOL Master; Carl Zeiss Meditec, Dublin, CA, USA), five OCT scans with Cirrus OCT: three peripapillary RNFL scans (Optic Disc Cube 200X200 protocol) and two macular scans (Macular Cube 512X128 protocol). One eye of each subject was selected randomly for analysis.
Two hundred eighty-three children (117 boys, 41.34%; 166 girls, 58.66%) were included in this study. The mean age of the children was 9.58 ± 3.12 years (range, 4-17). The mean SE was +0.63 ± 1.65 D; (range, -4.88 to +5.25). The mean AL was 22.94 ± 1.10 mm (range, 20.10-26.27). The mean global RNFL thickness was 97.40 ± 9.0 μm (range, 77-121.7 μm). Multivariate analysis showed a positive correlation between the RNFL and spherical equivalent (SE) (p = 0.014). The mean central macular thickness was 253.85 ± 19.76 μm, the average thickness 283.62 ± 14.08 μm, and the mean macular volume 10.22 ± 0.49 μm(3) . Multivariate analysis showed a positive correlation between central macular thickness and age (p < 0.001). Boys had a significantly thicker central macula than girls (p < 0.001).
Normative paediatric SD-OCT data might facilitate use of SD-OCT for assessing childhood ophthalmic diseases. This study provides a multicenter paediatric normative database of SD-OCT peripapillary RNFL and macular data.
使用谱域光相干断层扫描（SD-OCT）编译 4-17 岁健康白种人儿童的视网膜神经纤维层（RNFL）和黄斑厚度及黄斑体积的多中心标准数据库。分析 OCT 测量值随年龄、性别、屈光和眼轴（AL）的变化。
在西班牙的三个中心进行了一项观察性、多中心和横断面研究，共纳入 301 名健康白种人儿童。为了编制数据库，每个孩子都接受了散瞳眼部检查和睫状肌麻痹验光，五次 AL 测量（IOL Master；卡尔蔡司 Meditec，都柏林，CA，美国），五次 Cirrus OCT 扫描：三次视盘周围 RNFL 扫描（Optic Disc Cube 200X200 方案）和两次黄斑扫描（Macular Cube 512X128 方案）。每个受试者的一只眼睛被随机选择进行分析。
本研究纳入 283 名儿童（男 117 名，41.34%；女 166 名，58.66%）。儿童的平均年龄为 9.58 ± 3.12 岁（4-17 岁）。平均 SE 为+0.63 ± 1.65 D；（范围，-4.88 至+5.25）。平均 AL 为 22.94 ± 1.10 mm（范围，20.10-26.27）。平均全层 RNFL 厚度为 97.40 ± 9.0 μm（范围，77-121.7 μm）。多变量分析显示，RNFL 与球镜等效（SE）呈正相关（p = 0.014）。中央黄斑厚度平均为 253.85 ± 19.76 μm，平均厚度为 283.62 ± 14.08 μm，平均黄斑体积为 10.22 ± 0.49 μm(3)。多变量分析显示，中央黄斑厚度与年龄呈正相关（p < 0.001）。男孩的中央黄斑厚度明显比女孩厚（p < 0.001）。
SD-OCT 正常儿科数据可能有助于使用 SD-OCT 评估儿童眼病。本研究提供了一个多中心的儿科 SD-OCT 视盘周围 RNFL 和黄斑数据的正常数据库。
