Pérez-García Diana, Ibañez-Alperte Juan, Remón León, Cristóbal José Ángel, Sanchez-Cano Ana, Pinilla Isabel
Department of Ophthalmology, "Lozano Blesa" University Hospital, Zaragoza - Spain.
IIS Aragon, Aragon Health Sciences Institute, Zaragoza - Spain.
Eur J Ophthalmol. 2016 Mar-Apr;26(2):135-41. doi: 10.5301/ejo.5000665. Epub 2015 Sep 22.
To establish normal values for retinal nerve fiber layer (RNFL), macular thickness, and macular volume in children using spectral-domain optical coherence tomography (OCT).
A descriptive cross-sectional study was performed in healthy children between 3 and 14 years of age. Each child underwent a comprehensive ophthalmic examination that included 3 OCT scans with Spectralis (Heidelberg Engineering, Heidelberg, Germany). All measurements were performed by the same operator, and one eye was randomly selected. The influence of age, sex, and refraction on OCT measurements was analyzed.
The sample consisted of 162 Caucasian subjects, mean age 8.1 ± 3.03 years. The spherical equivalent was 0.03 ± 0.19 D (range ±4 D, astigmatism <1 D). The average values were 263.69 ± 4.54 µm for central macular thickness, 0.21 ± 0.01 mm3 for central macular volume, and 100.45 ± 1.98 µm for RNFL. A significant correlation between RNFL and spherical equivalent was found for the nasal (p = 0.001), inferior (p = 0.009), and inferior nasal (p = 0.005) sectors. No differences were found with regard to sex (p>0.05). However, central macular thickness and central macular volume were correlated with age (p = 0.027, p = 0.02).
This study provides reference values for macular thickness, macular volume, and RNFL in healthy children.
利用频域光学相干断层扫描（OCT）建立儿童视网膜神经纤维层（RNFL）、黄斑厚度和黄斑体积的正常值。
对3至14岁的健康儿童进行描述性横断面研究。每个儿童都接受了全面的眼科检查，包括使用Spectralis（德国海德堡海德堡工程公司）进行3次OCT扫描。所有测量均由同一名操作人员进行，随机选择一只眼睛。分析年龄、性别和屈光度对OCT测量结果的影响。
样本包括162名白种人受试者，平均年龄8.1±3.03岁。等效球镜度为0.03±0.19 D（范围±4 D，散光<1 D）。中心黄斑厚度的平均值为263.69±4.54 µm，中心黄斑体积为0.21±0.01 mm³，RNFL为100.45±1.98 µm。发现RNFL与等效球镜度在鼻侧（p = 0.001）、下方（p = 0.009）和鼻下（p = 0.005）象限存在显著相关性。在性别方面未发现差异（p>0.05）。然而，中心黄斑厚度和中心黄斑体积与年龄相关（p = 0.027，p = 0.02）。
本研究提供了健康儿童黄斑厚度、黄斑体积和RNFL的参考值。
