De Stefani Antonella, Boffano Paolo, Averono Gianluca, Ramella Angela, Pia Francesco, Bongioannini Guido
Division of Otorhinolaryngology, Ospedale Umberto I, Turin, Italy.
J Craniofac Surg. 2013 Jan;24(1):e40-3. doi: 10.1097/SCS.0b013e31826cfffa.
The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer.
The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types.
In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05).
A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.
本前瞻性研究的目的是分析一系列连续性口咽癌患者的人乳头瘤病毒（HPV）感染状况及其对预后的影响。
获取接受手术治疗的连续性口咽鳞状细胞癌患者的标本。样本通过扫帚型细胞采样装置采集，并进行罗氏线性阵列HPV基因分型检测以确定HPV类型的存在。
共纳入52例患者。在13个样本中检测到HPV存在，其中HPV16型是最常见的类型。HPV阳性患者与更高的肿瘤分级之间存在统计学显著关联（P < 0.05），HPV阳性患者与更多的负面预后因素之间也存在统计学显著关联（P < 0.05）。
一部分肿瘤分级较高的口咽鳞状细胞癌与HPV16感染密切相关。
