Inonu University School of Medicine, Department of Ophthalmology, Malatya, Turkey.
Food Chem Toxicol. 2013 May;55:371-7. doi: 10.1016/j.fct.2012.12.061. Epub 2013 Jan 21.
This study was designed in order to investigate whether sun dried apricots have a preventive effect on the experimental cataract model formed by sodium selenite in rats. Fifty-nine Spraque-Dawley rat pups were divided into three groups. Group 1 (control group) consisted of twenty rat pups, born from the rats nourished ad libitum. Group 2 consisted of 18 newborn rats, born from the rats nourished ad libitum with 10% sun dried natural apricots. Group 3 consisted of 21 newborn rats, born from the rats nourished ad libitum. Subcutaneous (30nmol/gr) sodium selenite injection was applied to all the newborn rats except the control group (Group 1) on postpartum day 10. Cataract development was graded by slit-lamp examination and photography. Encapsulated lenses were analyzed for reduced glutathione (GSH) and malondialdehyde (MDA), a marker of lipid per oxidation. Lenses were also analyzed for total nitrite (TN). The presence of oxidative stress in selenite cataract development and its prevention by sun dried apricots.
本研究旨在探讨自然晾晒的杏干是否对亚硒酸钠诱导的大鼠实验性白内障有预防作用。59 只斯普拉格-道利大鼠幼崽分为三组。第 1 组（对照组）由 20 只自由饮食的大鼠所生的幼崽组成。第 2 组由 18 只自由饮食的大鼠所生的幼崽组成，这些大鼠的饮食中添加了 10%的天然晾晒杏干。第 3 组由 21 只自由饮食的大鼠所生的幼崽组成。除对照组（第 1 组）外，所有新生大鼠于产后第 10 天皮下注射（30nmol/gr）亚硒酸钠。通过裂隙灯检查和摄影对白内障的发展进行分级。用分光光度法分析包被晶状体中的还原型谷胱甘肽（GSH）和丙二醛（MDA），MDA 是脂质过氧化的标志物。还分析了晶状体中的总亚硝酸盐（TN）。探讨了氧化应激在亚硒酸钠白内障发展中的作用以及自然晾晒杏干对其的预防作用。
