Rashidi Somayyeh, Chegeni Sara Aghakhani, Roozbahani Golbarg, Rahbarghazi Reza, Rezabakhsh Aysa, Reiter Russel J
Department of Medical Biotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Res Ther. 2025 Aug 5;16(1):424. doi: 10.1186/s13287-025-04531-y.
Ischemic diseases, especially coronary artery diseases and myocardial infarction, are the leading cause of human death in the clinical setting. Unfortunately, most of the available clinical interventions can partially restore the function of ischemic myocardium, resulting in the progression of chronic heart failure.The induction of vascular tissue formation, hereafter known as angiogenesis, can provide blood perfusion and prevent the expansion of ischemia-related pathologies. In recent years, the discovery and advent of multiple stem cells into human regenerative medicine have led to the alleviation of certain end-stage pathological conditions via direct differentiation into the mature and functional cells or secretion of various cytokines and angiogenesis factors in a paracrine manner. Melatonin (mel) is a natural molecule with direct and indirect pleiotropic actions on different biological phenomena. This neurohormone is primarily known for its antioxidant, tumoricidal, and anti-inflammatory actions in several pathological conditions. Whether and how mel regulates the angiogenesis behavior of stem cells is currently under debate. Here, we collected and evaluated recent data related to the angiogenic properties of mel on stem cells. Data from the present article may help us in the development of new therapeutic regimes in patients with ischemic conditions.
缺血性疾病，尤其是冠状动脉疾病和心肌梗死，是临床环境中人类死亡的主要原因。不幸的是，大多数现有的临床干预措施只能部分恢复缺血心肌的功能，导致慢性心力衰竭的进展。诱导血管组织形成，即血管生成，可以提供血液灌注并防止缺血相关病理状况的扩展。近年来，多种干细胞在人类再生医学中的发现和应用，通过直接分化为成熟的功能细胞或以旁分泌方式分泌各种细胞因子和血管生成因子，减轻了某些终末期病理状况。褪黑素（mel）是一种对不同生物现象具有直接和间接多效性作用的天然分子。这种神经激素主要因其在几种病理状况下的抗氧化、杀肿瘤和抗炎作用而闻名。褪黑素是否以及如何调节干细胞的血管生成行为目前仍存在争议。在此，我们收集并评估了近期与褪黑素对干细胞血管生成特性相关的数据。本文的数据可能有助于我们为缺血性疾病患者开发新的治疗方案。
