Mandel Louis
Salivary Gland Center, Oral and Maxillofacial Surgery, Columbia University College of Dental Medicine, New York, NY 10032, USA.
J Oral Maxillofac Surg. 2013 Feb;71(2):e76-80. doi: 10.1016/j.joms.2012.09.018.
The aim of this study is to call attention to the role that radioactive iodine ((131)I) and stapes surgery may play in causing hyposalivation.
The manner in which (131)I and stapes surgery can cause salivary damage was reviewed. A case report is presented to illustrate the involved pathophysiology.
The case report clearly shows the significant injury to the parotid glands caused by the (131)I. However, subjective symptoms of oral dryness only developed after injury to the chorda tympani nerve (CTN) during stapes surgery.
The loss of function of both parotid glands after (131)I therapy for thyroid cancer was initially compensated by the secretions of the more radiation-resistant submandibular and sublingual salivary glands (SMSG/SLSG). Damage to the CTN's secretory fibers in one SMSG/SLSG complex led to subjective oral dryness by accentuating an existing objective hyposalivation.
本研究的目的是提醒人们关注放射性碘（¹³¹I）和镫骨手术在导致唾液分泌减少方面可能起的作用。
回顾了¹³¹I和镫骨手术导致唾液腺损伤的方式。并通过一个病例报告来说明其中涉及的病理生理过程。
该病例报告清楚地显示了¹³¹I对腮腺造成的严重损伤。然而，口干的主观症状直到镫骨手术中鼓索神经（CTN）受损后才出现。
甲状腺癌¹³¹I治疗后双侧腮腺功能丧失最初由更耐辐射的下颌下腺和舌下腺（SMSG/SLSG）的分泌来代偿。一个SMSG/SLSG复合体中CTN分泌纤维的损伤，通过加重已存在的客观唾液分泌减少，导致了口干的主观症状。
