Institute of Fisheries Science, National Taiwan University, Taipei, 106, Taiwan.
Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
J Food Drug Anal. 2021 Dec 15;29(4):606-621. doi: 10.38212/2224-6614.3375.
Eight new diterpenes, 6α,7β-dihydroxyferruginol (1), 6α,7α-dihydroxyferruginol (2), 6α-hydroxyhinokiol (3), 4α-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4α-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7α-acetoxyabieta-8,12-diene-11,14-dione (7), 7α-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along with four known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7α-11-dihydroxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolated from the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data (appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. In conclusion, the results revealed the anti-lymphangiogenic potentials of Formosan C. macrolepis var. formosana.
从台湾翠柏的树皮中成功分离得到了 8 个新的二萜类化合物，分别为 6α,7β-二羟基土木香醇（1）、6α,7α-二羟基土木香醇（2）、6α-羟基厚朴酚（3）、4α-羟基-7-氧代-18-降柏-8,11,13-三烯-4α-醇（4a）、15,16-脱水贝壳杉二醇（5）、7-甲氧基-6,7-去氢柏-8,11,13-三烯-6,12-二醇（6）、7α-乙酰氧基柏-8,12-二烯-11,14-二酮（7）、7α-丁氧基乙氧基柏-8,12-二烯-11,14-二酮（8），以及 4 个已知化合物，6,7-脱氢土木香醇（9）、12-羟基-6,7-去氢柏-8,11,13-三烯-6,7-二醛（10）、7α-11-二羟基-12-甲氧基-8,11,13-贝壳松三烯（11）和 11,14-二羟基-8,11,13-贝壳松三烯-7-酮（12）。所有分离物的结构均通过物理数据（外观、UV、IR、旋光）和光谱数据（1D、2D NMR 和 HREIMS）阐明。化合物 9、10、11 和 12 对人淋巴管内皮细胞（LECs）表现出良好的生长抑制作用。在这些化合物中，化合物 10 通过抑制 LECs 的细胞生长和管形成，表现出最强的抗淋巴管生成活性。总之，结果表明台湾翠柏具有抗淋巴管生成潜力。
